{"id":"W2063299488","doi":"10.1385/cbb:43:2:221","title":"Constitutive Inactivation of the hKv1.5 Mutant Channel, H463G, in K<SUP>+</SUP>-Free Solutions at Physiological pH","year":2005,"lang":"en","type":"article","venue":"Cell Biochemistry and Biophysics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Repolarization; Extracellular; Chemistry; Depolarization; Biophysics; Conductance; Membrane potential; Intracellular; Potassium channel; Potassium; Mutant; Biochemistry; Electrophysiology; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003129477,0.0003057967,0.0003818111,0.0001023839,0.0001814409,0.0004682812,0.0005047,0.000438305,0.001165136],"category_scores_gemma":[0.0003789817,0.0001759823,0.0002163983,0.0002747429,0.0004554006,0.0004179818,0.0002508168,0.0006532108,0.0004268068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005263865,"about_ca_system_score_gemma":0.0004114882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003113476,"about_ca_topic_score_gemma":0.001979366,"domain_scores_codex":[0.9996905,0.00004839325,0.00004411381,0.00005865051,0.00007568408,0.00008262226],"domain_scores_gemma":[0.9997243,0.00006940979,0.00006439051,0.00004689055,0.00002485531,0.00007014417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003947748,0.00002874618,0.0001924425,0.00003800685,0.000007313568,0.00007663798,0.00004467045,0.0001079187,0.9983266,0.0002174351,0.00007316328,0.0004923501],"study_design_scores_gemma":[0.0000733031,0.000234546,0.004405499,0.00001176052,0.00001933851,0.0002800113,0.00006468143,0.002737262,0.9909884,0.00009132956,0.001079897,0.000013886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977922,0.0002973861,0.0006965442,0.0000761658,0.00002344082,0.00001113897,0.0004178725,0.00004806874,0.0006372296],"genre_scores_gemma":[0.997806,0.0001586524,0.0004857906,0.0000332841,0.00000820442,0.0000104614,0.0004405875,0.00002705986,0.001029994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113476,"threshold_uncertainty_score":0.006190717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257916012278838,"score_gpt":0.2068352182637341,"score_spread":0.1942560581409458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}