{"id":"W2063354139","doi":"10.2174/157016410790979644","title":"An Update on Prion Biology and Proteomics","year":2010,"lang":"en","type":"article","venue":"Current Proteomics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Proteomics; Neurodegeneration; Biology; Mechanism (biology); Prion protein; Gene isoform; Scrapie; Infectivity; Neurotoxicity; Computational biology; Virology; Toxicity; Genetics; Chemistry; Disease; Medicine; Gene; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126705,0.0001861152,0.0001249166,0.00004668137,0.0001245293,0.0000574047,0.0002312573,0.0001863527,0.00002077811],"category_scores_gemma":[0.00009193001,0.000172015,0.00005402702,0.00004550545,0.0001048448,0.000008588925,0.0001162368,0.00028018,0.0000143857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007512545,"about_ca_system_score_gemma":0.00007772722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003020083,"about_ca_topic_score_gemma":0.000006462597,"domain_scores_codex":[0.9989823,0.00005411943,0.0001757151,0.0004652225,0.00006506991,0.0002576511],"domain_scores_gemma":[0.999204,0.000004515159,0.00009576454,0.0004611302,0.00005258563,0.000182032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249753,0.00008946649,0.003318744,0.00002177829,0.000008906056,3.754504e-7,0.00001039572,0.000005059746,0.850411,0.002339679,0.00008434484,0.1435853],"study_design_scores_gemma":[0.001063765,0.0007774791,0.00300646,0.00003169627,0.00002140595,0.00001520859,0.000009990074,0.0006219587,0.8496615,0.004025014,0.1402144,0.0005510557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922696,0.001423505,0.004767639,0.0001700129,0.0004624936,0.0007923223,0.00005062252,0.00002762191,0.00003613045],"genre_scores_gemma":[0.9874068,0.002075511,0.00928054,0.0001807641,0.0006192247,0.0001440191,0.0002538798,0.00003015759,0.000009118558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1430342,"threshold_uncertainty_score":0.7014568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009236432333425654,"score_gpt":0.3122058657792087,"score_spread":0.302969433445783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}