{"id":"W2063400663","doi":"10.1172/jci42703","title":"Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Harvard Digestive Diseases Center, Harvard University; Deutsche Forschungsgemeinschaft; Brigham and Women's Hospital; National Cancer Institute; National Institutes of Health; Cancer Research UK; Crohn's and Colitis Foundation; Lister Institute of Preventive Medicine; Wellcome Trust; National Heart, Lung, and Blood Institute; Crohn's and Colitis Foundation of America","keywords":"Microsomal triglyceride transfer protein; CD1; CD1D; Immune system; Biology; Antigen presentation; Lipid metabolism; Antigen; Chemistry; Lipoprotein; T cell; Immunology; Antigen-presenting cell; Biochemistry; Natural killer T cell; Cholesterol; Very low-density lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263651,0.0005719706,0.0002642764,0.0005535795,0.0002641001,0.0002256344,0.000124977,0.0003961614,0.002754353],"category_scores_gemma":[0.0002822135,0.0001306166,0.0001116163,0.0001801123,0.0003088152,0.00013233,0.0003068399,0.000317928,0.0006042387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849413,"about_ca_system_score_gemma":0.0001132195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003681494,"about_ca_topic_score_gemma":0.0002121302,"domain_scores_codex":[0.9998804,0.00002655054,0.00001373717,0.00002734477,0.00002693537,0.00002501248],"domain_scores_gemma":[0.9999053,0.00002326218,0.00002260108,0.000006498702,0.00001151282,0.00003063805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002634296,0.0003573167,0.03627224,0.0002404604,0.00007607532,0.06280632,0.0002565846,0.0001927177,0.8786919,0.0007993341,0.001524222,0.01614851],"study_design_scores_gemma":[0.0002651628,0.001487472,0.3243387,0.00009740199,0.000253354,0.3358316,0.0002602899,0.002850828,0.3104415,0.0008814761,0.02325351,0.00003874639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952427,0.0009922114,0.0007159158,0.000122634,0.00002583121,0.00002356624,0.0001497045,0.00007455529,0.002652792],"genre_scores_gemma":[0.9973512,0.0003738378,0.0004261328,0.00007047984,0.0000199463,0.00001220949,0.0002483092,0.00001392224,0.001483937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002754353,"threshold_uncertainty_score":0.009214282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611369904497336,"score_gpt":0.2892956699414767,"score_spread":0.2631819708965034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}