{"id":"W2063400663","doi":"10.1172/jci42703","title":"Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Harvard Digestive Diseases Center, Harvard University; Deutsche Forschungsgemeinschaft; Brigham and Women's Hospital; National Cancer Institute; National Institutes of Health; Cancer Research UK; Crohn's and Colitis Foundation; Lister Institute of Preventive Medicine; Wellcome Trust; National Heart, Lung, and Blood Institute; Crohn's and Colitis Foundation of America","keywords":"Microsomal triglyceride transfer protein; CD1; CD1D; Immune system; Biology; Antigen presentation; Lipid metabolism; Antigen; Chemistry; Lipoprotein; T cell; Immunology; Antigen-presenting cell; Biochemistry; Natural killer T cell; Cholesterol; Very low-density lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001589793,0.0001307914,0.0005753316,0.0002084739,0.00005263106,0.000007191597,0.0001351176,0.0004226188,0.0003606144],"category_scores_gemma":[0.0004941842,0.0001015076,0.0002102631,0.0002451138,0.0004935766,0.0003013679,0.00001165162,0.001096988,0.000006074541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003105121,"about_ca_system_score_gemma":0.0002305091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007677882,"about_ca_topic_score_gemma":0.00005703244,"domain_scores_codex":[0.9972945,0.0003100062,0.001982969,0.0001512591,0.000115648,0.0001456272],"domain_scores_gemma":[0.9978727,0.0001773306,0.001278422,0.0001502768,0.0004893463,0.00003194126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001615118,0.0004043926,0.02764294,0.00003574646,0.00009848151,0.000001911057,0.0001877506,0.00000682058,0.9684233,0.000198321,0.0002471863,0.001138009],"study_design_scores_gemma":[0.00515501,0.002390483,0.1992289,0.0003057672,0.00009923655,0.00003776121,0.00006825553,0.000006078314,0.7915665,0.0004117387,0.000617944,0.0001123683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978123,0.00008940003,0.0002437885,0.0001864671,0.001114175,0.0002521852,0.000003163148,0.000008100428,0.0002904206],"genre_scores_gemma":[0.9989442,0.000009086704,0.0001199994,0.0001505926,0.0000537598,0.000004550506,0.00003669965,0.00001154227,0.0006696303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1768568,"threshold_uncertainty_score":0.4765928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611369904497336,"score_gpt":0.2892956699414767,"score_spread":0.2631819708965034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}