{"id":"W2063461386","doi":"10.1016/j.ymgme.2010.12.001","title":"Experience over fifteen years with a protocol for predictive testing for Huntington disease","year":2010,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Group for Research in Decision Analysis","funders":"","keywords":"Predictive testing; Medicine; Test (biology); Cohort; Psychiatry; Clinical psychology; Disease; Protocol (science); Telephone interview; Genetic testing; Retrospective cohort study; Family medicine; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000674808,0.0002037977,0.0001620082,0.00005569293,0.0001594362,0.0001126935,0.0001909779,0.00004007451,0.000006767135],"category_scores_gemma":[0.0008378098,0.0001785998,0.00006136713,0.0001389399,0.0001787724,0.00004965073,0.00008276065,0.00008617894,5.607909e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002918153,"about_ca_system_score_gemma":0.000105484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003038296,"about_ca_topic_score_gemma":0.000002048298,"domain_scores_codex":[0.9985892,0.0000398773,0.0001697668,0.0006281,0.0002371935,0.0003358731],"domain_scores_gemma":[0.9990773,0.0001197545,0.0001014059,0.0003200089,0.0001305019,0.000251043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001697316,0.00007476833,0.001670737,0.00003771011,0.000004847142,0.000004109447,0.0001592227,0.0001927268,0.9942825,0.0007824191,0.00002989742,0.002591365],"study_design_scores_gemma":[0.001783981,0.000196655,0.06876148,0.00001487143,0.00006302216,0.000001864569,0.00001219563,0.003781146,0.9061107,0.001054394,0.01795706,0.0002626298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421607,0.00002121241,0.007705059,0.00003607391,0.00009444684,0.04976135,0.0001323902,0.00003578199,0.00005300812],"genre_scores_gemma":[0.8126403,0.000001196184,0.01596715,0.000530851,0.0001186056,0.1706392,0.000003053084,0.00005381067,0.00004581081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1295204,"threshold_uncertainty_score":0.7283088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02368278109499741,"score_gpt":0.2999192326842139,"score_spread":0.2762364515892165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}