{"id":"W2063468574","doi":"10.1016/j.bbagrm.2011.11.013","title":"Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation","year":2011,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"PCAF; Acetylation; Bromodomain; Transcription factor; P300-CBP Transcription Factors; Lysine; CREB-binding protein; Histone; Gene isoform; Biology; Cell biology; Transcription (linguistics); Transcriptional regulation; Gene; Chemistry; Molecular biology; Genetics; Histone Acetyltransferases; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205476,0.0002796196,0.0003261648,0.0003637079,0.0004329552,0.0003085565,0.0005909841,0.0005149439,0.001960257],"category_scores_gemma":[0.0003316651,0.0002902749,0.0004629119,0.0002397106,0.0004668914,0.0002550689,0.0002363169,0.0005982204,0.0008597554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000664108,"about_ca_system_score_gemma":0.0003036414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547592,"about_ca_topic_score_gemma":0.002478816,"domain_scores_codex":[0.9998896,0.0000173259,0.00000822414,0.00002918732,0.00002816111,0.00002751419],"domain_scores_gemma":[0.9997095,0.00008223024,0.00006933937,0.00003527355,0.000028232,0.00007537219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000652153,0.00007625677,0.001436412,0.00004409327,0.00001830922,0.0002075176,0.00002503583,0.0003116992,0.9947184,0.0002995561,0.00006697394,0.002143734],"study_design_scores_gemma":[0.00007379374,0.0001412085,0.02681123,0.000007531434,0.00002387346,0.0007604625,0.00003056489,0.002090291,0.968614,0.000281864,0.001152705,0.00001251457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905944,0.0006543529,0.007297444,0.0001142497,0.00003345528,0.00003114849,0.000241744,0.00005977418,0.0009734121],"genre_scores_gemma":[0.9964484,0.0001417261,0.002156099,0.00004751312,0.00001029731,0.00001562636,0.0003504066,0.00001620745,0.0008136625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001960257,"threshold_uncertainty_score":0.006557703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04921674707311672,"score_gpt":0.242125326298066,"score_spread":0.1929085792249493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}