{"id":"W2063470457","doi":"10.1016/j.ccr.2012.05.023","title":"Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Research Council; Helmholtz Association; Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; Cross Cancer Institute","keywords":"Extravasation; CCR2; Metastasis; Cancer research; Leukocyte extravasation; CCL2; Chemokine; Downregulation and upregulation; CCL5; Medicine; Endothelium; Biology; Immunology; Chemokine receptor; Inflammation; Internal medicine; T cell; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256016,0.0002710693,0.0001729864,0.0002457005,0.0002218756,0.0004516259,0.0001103565,0.0002511822,0.002764184],"category_scores_gemma":[0.0001069635,0.0001254144,0.0002809351,0.0002090921,0.0001339958,0.0002767235,0.0002362858,0.0008061877,0.0005013169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003811215,"about_ca_system_score_gemma":0.0004110131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723755,"about_ca_topic_score_gemma":0.002873523,"domain_scores_codex":[0.9996804,0.00005153643,0.00001267651,0.00002474731,0.00006323752,0.0001673878],"domain_scores_gemma":[0.9999422,0.00000757371,0.00001120093,0.000007923808,0.000007131655,0.00002391316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003544402,0.0000802227,0.0004297068,0.00005352313,0.000008886735,0.0001850754,0.00002645787,0.0001010585,0.9964341,0.0004034074,0.0002936916,0.001629334],"study_design_scores_gemma":[0.00007420842,0.0004351709,0.01345051,0.000009436629,0.00002197938,0.0005291703,0.0001159432,0.002052454,0.9777295,0.0000941234,0.005479232,0.000008236019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928393,0.001904256,0.001129759,0.0002695401,0.0000554779,0.00001833325,0.000362207,0.00006254691,0.003358517],"genre_scores_gemma":[0.9962119,0.0004051619,0.0004286243,0.0000451869,0.00001166622,0.00001568163,0.0003534219,0.000004780461,0.002523765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002764184,"threshold_uncertainty_score":0.009247184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809358023044687,"score_gpt":0.2407578065292426,"score_spread":0.2226642262987957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}