{"id":"W2063470457","doi":"10.1016/j.ccr.2012.05.023","title":"Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Research Council; Helmholtz Association; Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; Cross Cancer Institute","keywords":"Extravasation; CCR2; Metastasis; Cancer research; Leukocyte extravasation; CCL2; Chemokine; Downregulation and upregulation; CCL5; Medicine; Endothelium; Biology; Immunology; Chemokine receptor; Inflammation; Internal medicine; T cell; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002626759,0.0001803103,0.0002310606,0.00002684224,0.0001397012,0.00002830445,0.00006806794,0.0001117339,0.0003584783],"category_scores_gemma":[0.000009623029,0.0001289815,0.00006279358,0.00008759208,0.00004847548,0.0001120416,0.00003029594,0.0001967289,0.00001140224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001577872,"about_ca_system_score_gemma":0.00009635642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000760358,"about_ca_topic_score_gemma":0.00001566783,"domain_scores_codex":[0.9989411,0.00003869346,0.0002211455,0.0002141014,0.0002153069,0.0003696516],"domain_scores_gemma":[0.9993805,0.0001007547,0.0001099561,0.0001702368,0.0000597729,0.0001788169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000561077,0.0001341292,0.005639099,0.0001070882,0.00001766289,0.000001314931,0.00190644,0.000002589014,0.9851969,0.0000068933,0.001322836,0.005608963],"study_design_scores_gemma":[0.001894832,0.00009008424,0.00033264,0.00004115619,0.0000843,0.00000582402,0.0004981072,0.0001451821,0.9673364,0.00001705382,0.02939765,0.0001567967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873524,0.009888731,0.0002581742,0.0001840826,0.0004564394,0.0003603731,0.00003429171,0.00002964068,0.001435886],"genre_scores_gemma":[0.997315,0.0003304848,0.00007995794,0.0003692404,0.001006238,0.00004500926,0.00002535387,0.00003586862,0.0007927768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02807481,"threshold_uncertainty_score":0.5259714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809358023044687,"score_gpt":0.2407578065292426,"score_spread":0.2226642262987957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}