{"id":"W2063486260","doi":"10.1254/jphs.13224fp","title":"Transient Receptor Potential Melastatin 7 (TRPM7) Contributes to H2O2-Induced Cardiac Fibrosis via Mediating Ca2+ Influx and Extracellular Signal–Regulated Kinase 1/2 (ERK1/2) Activation in Cardiac Fibroblasts","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacological Sciences","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Sun Yat-sen University; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"TRPM7; CTGF; Cardiac fibrosis; Transient receptor potential channel; Chemistry; Cell biology; Small hairpin RNA; Fibrosis; Extracellular; Downregulation and upregulation; Intracellular; Signal transduction; Endocrinology; Internal medicine; Growth factor; Cancer research; Receptor; Biology; Apoptosis; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105259,0.0003320071,0.0004550928,0.0002236892,0.0002590446,0.0003607387,0.0001996952,0.0005690766,0.0008368511],"category_scores_gemma":[0.0001501777,0.0001463992,0.0005846557,0.0001323636,0.000321238,0.000440402,0.000235431,0.0006955519,0.0002930606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147802,"about_ca_system_score_gemma":0.0002272405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000259592,"about_ca_topic_score_gemma":0.0003145564,"domain_scores_codex":[0.9998324,0.00003052569,0.00001892574,0.00002973451,0.00003745597,0.00005097058],"domain_scores_gemma":[0.9999082,0.00001152149,0.00003267387,0.000006784463,0.00001604285,0.00002471653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002232779,0.00003699907,0.0002970574,0.0000884597,0.00001046815,0.0001075705,0.00001488411,0.0000414914,0.9977563,0.00009575627,0.00006368938,0.001264137],"study_design_scores_gemma":[0.00007053615,0.0006225829,0.007281342,0.00001494459,0.00007776146,0.0006886207,0.0001235694,0.00222683,0.9841933,0.0002610767,0.00442615,0.00001335337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795175,0.008464244,0.009128334,0.0006119327,0.0001550192,0.00007308606,0.0002206084,0.0001889715,0.001640265],"genre_scores_gemma":[0.9932359,0.00316777,0.001708242,0.0002327614,0.00003324078,0.0000500357,0.0002306094,0.000017373,0.001324052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008368511,"threshold_uncertainty_score":0.002799511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613380838275133,"score_gpt":0.2945789469867375,"score_spread":0.2784451386039862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}