{"id":"W2063486260","doi":"10.1254/jphs.13224fp","title":"Transient Receptor Potential Melastatin 7 (TRPM7) Contributes to H2O2-Induced Cardiac Fibrosis via Mediating Ca2+ Influx and Extracellular Signal–Regulated Kinase 1/2 (ERK1/2) Activation in Cardiac Fibroblasts","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacological Sciences","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Sun Yat-sen University; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"TRPM7; CTGF; Cardiac fibrosis; Transient receptor potential channel; Chemistry; Cell biology; Small hairpin RNA; Fibrosis; Extracellular; Downregulation and upregulation; Intracellular; Signal transduction; Endocrinology; Internal medicine; Growth factor; Cancer research; Receptor; Biology; Apoptosis; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002982426,0.0002391621,0.00056285,0.0003352957,0.0003715401,0.0001372243,0.0002700326,0.0001492917,0.0002374311],"category_scores_gemma":[0.0009699634,0.0001803147,0.0001649354,0.0008262235,0.0001896074,0.0004361108,0.00005084793,0.0003753105,0.000007015455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728007,"about_ca_system_score_gemma":0.0001246556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001162414,"about_ca_topic_score_gemma":0.000003664719,"domain_scores_codex":[0.996321,0.001003478,0.0009047047,0.0003863579,0.000762974,0.0006214827],"domain_scores_gemma":[0.9975121,0.0009279338,0.0004748685,0.00006982544,0.0003122918,0.0007030044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009792962,0.0001413117,0.004083841,0.00007341608,0.00001633426,0.000006229991,0.0003639851,0.003070152,0.9658017,0.00001034348,0.0006047687,0.02484858],"study_design_scores_gemma":[0.003296001,0.00398475,0.07451676,0.0001929515,0.0003234976,0.00000513734,0.0007000271,0.0145747,0.8997372,0.000514626,0.00160925,0.0005450635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910896,0.0005552975,0.0009655438,0.005459507,0.001293891,0.0005498247,0.00001898184,0.0000247562,0.00004263987],"genre_scores_gemma":[0.997501,0.00001260268,0.001320602,0.0006726594,0.000452572,0.00002006027,0.000004268773,0.000009798228,0.000006470422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07043292,"threshold_uncertainty_score":0.7353019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613380838275133,"score_gpt":0.2945789469867375,"score_spread":0.2784451386039862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}