{"id":"W2063497848","doi":"10.4161/15384101.2014.980700","title":"Targeted protein degradation as a tumor suppressor","year":2014,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Biology; Suppressor; Cancer research; Ubiquitin; Degradation (telecommunications); Cell biology; Protein degradation; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614975,0.000405148,0.000329212,0.0003754733,0.0002488884,0.000748941,0.0002690617,0.0004590969,0.002669685],"category_scores_gemma":[0.0002394591,0.00009293601,0.0002867135,0.000251785,0.0002820879,0.000309177,0.0004219474,0.0005877379,0.001665801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005604441,"about_ca_system_score_gemma":0.0001853012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001981948,"about_ca_topic_score_gemma":0.0001597373,"domain_scores_codex":[0.9997882,0.00002712122,0.00001296689,0.00005964088,0.00007527511,0.00003668479],"domain_scores_gemma":[0.999849,0.0000184514,0.00004301871,0.00002137385,0.00002836798,0.0000398153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002936597,0.0001265625,0.001624658,0.0003862317,0.00005158384,0.001587998,0.00005475822,0.0003454273,0.9162481,0.009703856,0.007047281,0.06252985],"study_design_scores_gemma":[0.00007340688,0.0007188351,0.009492584,0.00006375444,0.00008174499,0.01212819,0.00004944358,0.002918597,0.6931075,0.003775574,0.2775679,0.00002260879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6207932,0.2826697,0.03120674,0.005340747,0.00219276,0.0001936214,0.001702203,0.002430711,0.05347034],"genre_scores_gemma":[0.942481,0.02617732,0.002901841,0.001013814,0.0002633113,0.00005194936,0.0007809206,0.00007632588,0.02625336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002669685,"threshold_uncertainty_score":0.008930981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006092380785525473,"score_gpt":0.2114188763429014,"score_spread":0.2053264955573759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}