{"id":"W2063509208","doi":"10.1046/j.1365-2567.2002.01448.x","title":"Liposome/DNA complexes coated with biodegradable PLA improve immune responses to plasmid encoding hepatitis B surface antigen","year":2002,"lang":"en","type":"article","venue":"Immunology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"","keywords":"Naked DNA; DNA vaccination; Antigen; Immune system; Antibody; Molecular biology; Splenocyte; Biology; Genetic enhancement; Plasmid; In vivo; Gene gun; Liposome; Immunization; Virology; DNA; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000962737,0.0002602927,0.0003110403,0.00009338281,0.0001809517,0.00004454715,0.000379336,0.0002195325,0.000182335],"category_scores_gemma":[0.00006732994,0.0002318451,0.00007694519,0.0001744873,0.0001775148,0.00001127912,0.0001916494,0.0001463761,0.000247213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002563197,"about_ca_system_score_gemma":0.00004321797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005118629,"about_ca_topic_score_gemma":0.0002372624,"domain_scores_codex":[0.9985155,0.0001116768,0.0002926391,0.0004863426,0.0001061812,0.0004876447],"domain_scores_gemma":[0.9991156,0.00004099778,0.0001051693,0.0005290913,0.0001389336,0.00007016122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005920004,0.00007173273,0.01077021,0.000005926749,0.0002006657,0.00002128156,0.0001871465,0.0000312007,0.9852883,0.00001820629,0.001870014,0.0009433551],"study_design_scores_gemma":[0.0006305712,0.002268217,0.00804384,0.00003214786,0.00001538796,0.00007069098,0.0001575784,0.00006782301,0.9667844,0.000007632055,0.02158253,0.0003392481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938146,0.004013484,0.0002902127,0.0004201483,0.0003182124,0.0002341294,0.00009518117,0.00004415757,0.0007698943],"genre_scores_gemma":[0.9941263,0.001260612,0.000508752,0.0002889368,0.00006862306,0.00002178223,0.00007286271,0.00003304826,0.003619104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01971252,"threshold_uncertainty_score":0.9454368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492953786737336,"score_gpt":0.2278308404087096,"score_spread":0.2129013025413362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}