{"id":"W2063509208","doi":"10.1046/j.1365-2567.2002.01448.x","title":"Liposome/DNA complexes coated with biodegradable PLA improve immune responses to plasmid encoding hepatitis B surface antigen","year":2002,"lang":"en","type":"article","venue":"Immunology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"","keywords":"Naked DNA; DNA vaccination; Antigen; Immune system; Antibody; Molecular biology; Splenocyte; Biology; Genetic enhancement; Plasmid; In vivo; Gene gun; Liposome; Immunization; Virology; DNA; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572933,0.0004089435,0.0002392558,0.0001992395,0.00009092734,0.0003040521,0.0001914925,0.000336059,0.00100256],"category_scores_gemma":[0.0002619252,0.0001789594,0.0001391443,0.0000999488,0.0002717478,0.0003334488,0.0002145483,0.0003503897,0.0003874626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865162,"about_ca_system_score_gemma":0.0001713422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003185977,"about_ca_topic_score_gemma":0.0004290714,"domain_scores_codex":[0.9998665,0.00002651434,0.0000119141,0.00002791812,0.00003449045,0.00003264846],"domain_scores_gemma":[0.9998521,0.00003999294,0.00005000983,0.00001083248,0.00002180363,0.00002518944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000454052,0.00001869404,0.00006100692,0.0000211743,0.000002317518,0.000008767565,0.000005532393,0.00005432653,0.9987646,0.00003467534,0.000008248832,0.000975309],"study_design_scores_gemma":[0.00001719737,0.0002257642,0.0005780592,0.000002203769,0.00001183375,0.00004027353,0.000004319415,0.0006703309,0.9978896,0.00001599197,0.0005426569,0.000001834823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917113,0.001242943,0.005846132,0.0001019121,0.00002096214,0.00003678732,0.00004405798,0.00009053483,0.0009054877],"genre_scores_gemma":[0.9905764,0.0005489879,0.00683407,0.00006725105,0.0000131529,0.00002146189,0.00008950305,0.0000283344,0.001820864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00100256,"threshold_uncertainty_score":0.003353894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492953786737336,"score_gpt":0.2278308404087096,"score_spread":0.2129013025413362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}