{"id":"W2063509404","doi":"10.1371/journal.pone.0016648","title":"Propofol Directly Increases Tau Phosphorylation","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Hyperphosphorylation; Propofol; Phosphorylation; Hippocampus; Tau protein; Anesthetic; Protein phosphatase 2; Pharmacology; Chemistry; Medicine; Endocrinology; Internal medicine; Alzheimer's disease; Phosphatase; Anesthesia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271847,0.0006043371,0.0003422107,0.0001443116,0.0001736151,0.0003370434,0.0001230892,0.0003288745,0.002862824],"category_scores_gemma":[0.0003212846,0.0001484638,0.0003676052,0.0001421131,0.0002021913,0.0002687466,0.000335476,0.0007070316,0.0004031155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448017,"about_ca_system_score_gemma":0.0003157742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006178227,"about_ca_topic_score_gemma":0.0009711444,"domain_scores_codex":[0.9998418,0.00002487749,0.00001272131,0.00001707126,0.00004792171,0.00005551408],"domain_scores_gemma":[0.9998029,0.00003985802,0.000078201,0.00001629293,0.00002484868,0.00003806338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003052091,0.0003511365,0.001182126,0.0003461548,0.00005843352,0.0002897662,0.00007263657,0.0001746687,0.9776614,0.0002205649,0.0007523791,0.01583857],"study_design_scores_gemma":[0.000309329,0.008987458,0.03575697,0.00005376358,0.0001670921,0.0009363242,0.000105436,0.001434098,0.9435786,0.0002459121,0.008398262,0.00002685933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893839,0.005009512,0.001262545,0.0003036202,0.0002276085,0.00007030342,0.0004090741,0.0001560226,0.003177421],"genre_scores_gemma":[0.9930829,0.003252684,0.0009248841,0.0001555052,0.00005990503,0.00005794954,0.0005580228,0.00001500973,0.001893244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002862824,"threshold_uncertainty_score":0.009577036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08939701953422755,"score_gpt":0.281115710179322,"score_spread":0.1917186906450945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}