{"id":"W2063517469","doi":"10.1371/journal.pone.0077256","title":"Zhangfei/CREB-ZF – A Potential Regulator of the Unfolded Protein Response","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cameco (Canada); University of Saskatchewan","funders":"Canadian Institutes of Health Research; China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; Government of Jiangxi Province; University of Saskatchewan","keywords":"Unfolded protein response; Leucine zipper; ATF4; ATF6; XBP1; Cell biology; Endoplasmic reticulum; ATF3; Thapsigargin; Transcription factor; Biology; Activating transcription factor; CREB; Endoplasmic-reticulum-associated protein degradation; SOX4; Gene; Promoter; Gene expression; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325487,0.0004951443,0.000270516,0.0002494298,0.0002134945,0.0001775642,0.0004103362,0.0003035768,0.002046132],"category_scores_gemma":[0.00008170174,0.0001319612,0.0003336119,0.0001709626,0.0002579968,0.0001770292,0.0001989728,0.0006022715,0.0006639533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354218,"about_ca_system_score_gemma":0.0001930752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005821211,"about_ca_topic_score_gemma":0.0005144096,"domain_scores_codex":[0.9998759,0.00001341523,0.000006438255,0.00003063577,0.00003182224,0.00004173145],"domain_scores_gemma":[0.9999353,0.000007366069,0.00001855446,0.000007683423,0.000007647027,0.00002346994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001609525,0.00003063741,0.0001106325,0.00003480707,0.000004971218,0.00006864008,0.000005377891,0.00004705562,0.9973883,0.00009470136,0.00009580598,0.00195811],"study_design_scores_gemma":[0.00004612246,0.000282092,0.003427112,0.000005968107,0.00001455623,0.0004486681,0.000013512,0.0007766432,0.9890537,0.000067616,0.005853313,0.00001078868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703814,0.006882044,0.01408833,0.0003958044,0.000208374,0.0001608784,0.002159565,0.000795164,0.004928532],"genre_scores_gemma":[0.9828515,0.001242647,0.006622123,0.0001653406,0.0000402031,0.00009056593,0.002139639,0.00005045543,0.006797512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046132,"threshold_uncertainty_score":0.006844997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00908608243888536,"score_gpt":0.1837100559364175,"score_spread":0.1746239734975321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}