{"id":"W2063547833","doi":"10.1021/bi1014453","title":"Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP-1, and SHP-2","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Protein tyrosine phosphatase; Tyrosine; Dephosphorylation; Chemistry; Phosphatase; Residue (chemistry); Peptide; Substrate (aquarium); Active site; Aromatic amino acids; Stereochemistry; Biochemistry; Phosphorylation; SH2 domain; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183776,0.0004342032,0.0003167992,0.0002985456,0.0001076237,0.000361225,0.0002193266,0.0002194647,0.0006034764],"category_scores_gemma":[0.0003808723,0.0001810844,0.0001699837,0.0002873293,0.0001143625,0.0001537699,0.0001714275,0.0002568474,0.0003141719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140928,"about_ca_system_score_gemma":0.000147874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005638336,"about_ca_topic_score_gemma":0.0005858233,"domain_scores_codex":[0.999605,0.00006885138,0.00003044439,0.00008100807,0.0001444111,0.00007037989],"domain_scores_gemma":[0.9998263,0.00004549952,0.00004259927,0.00001526798,0.00003617713,0.00003427338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147462,0.00001519672,0.001041262,0.00002830742,0.000008995844,0.0000304194,0.000008429379,0.0003388026,0.9968815,0.00002297684,0.00002254915,0.001486741],"study_design_scores_gemma":[0.00001693703,0.0002546134,0.01282717,0.000005425566,0.00002754063,0.0004016871,0.00002613185,0.003358933,0.9819623,0.00004666644,0.001066082,0.000006513126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959301,0.001007054,0.001686542,0.00002409718,0.000006161908,0.00001547155,0.0003641024,0.0000205357,0.000945833],"genre_scores_gemma":[0.9953366,0.000634661,0.001653152,0.00003154456,0.000005084434,0.00003054002,0.001329554,0.00001302135,0.0009658569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006034764,"threshold_uncertainty_score":0.002018809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819755656884845,"score_gpt":0.2213475899080435,"score_spread":0.2031500333391951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}