{"id":"W2063547833","doi":"10.1021/bi1014453","title":"Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP-1, and SHP-2","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Protein tyrosine phosphatase; Tyrosine; Dephosphorylation; Chemistry; Phosphatase; Residue (chemistry); Peptide; Substrate (aquarium); Active site; Aromatic amino acids; Stereochemistry; Biochemistry; Phosphorylation; SH2 domain; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001563397,0.0002976311,0.000254629,0.0000256866,0.00006492872,0.00001987572,0.0003250498,0.0002323888,0.0001322793],"category_scores_gemma":[0.000146469,0.0002975754,0.00009017392,0.0001134477,0.0003763682,0.000008941836,0.0002331138,0.0001098561,0.00000840389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001315736,"about_ca_system_score_gemma":0.0001019087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001169769,"about_ca_topic_score_gemma":0.000007687976,"domain_scores_codex":[0.9985331,0.00002561361,0.0003615429,0.0005737338,0.0001725232,0.0003334476],"domain_scores_gemma":[0.9988265,0.000007723035,0.0002098184,0.000675792,0.0001162545,0.0001638966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002814409,0.0002401796,0.002624446,0.0001756007,0.00004893683,0.00001197629,0.00001841076,2.018479e-7,0.9937561,0.0007972787,0.001251985,0.000793478],"study_design_scores_gemma":[0.0006771946,0.0001974412,0.003450633,0.00006982273,0.00002575513,0.00002482221,0.00005440967,0.000003217529,0.9935788,0.0001630617,0.001427186,0.0003276759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722449,0.02504421,0.0001418886,0.00002953176,0.00005373811,0.0003202191,0.000516862,0.0000296803,0.001619023],"genre_scores_gemma":[0.9957924,0.000290929,0.002734824,0.00004984963,0.0001535755,0.00005144406,0.0004323933,0.0000352916,0.00045924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02475328,"threshold_uncertainty_score":0.9999476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819755656884845,"score_gpt":0.2213475899080435,"score_spread":0.2031500333391951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}