{"id":"W2063550283","doi":"10.1021/jm3004587","title":"Protein–Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I–XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Carbonic anhydrase; Transferrin; Carbonic anhydrase II; Biochemistry; Gene isoform; Enzyme; Lactoferrin; Carbonic Anhydrase I; Isozyme; Enzyme inhibitor; Surface plasmon resonance; Protease inhibitor (pharmacology); Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789242,0.0002402589,0.0002555173,0.00009392495,0.00009206295,0.0001500602,0.0002562352,0.0002125456,0.000436594],"category_scores_gemma":[0.000130746,0.0000742168,0.0001922436,0.0001264108,0.00009718248,0.0000850988,0.00008361477,0.0002662313,0.0001369764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192042,"about_ca_system_score_gemma":0.0001520027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710236,"about_ca_topic_score_gemma":0.002116577,"domain_scores_codex":[0.9998481,0.00003289121,0.00001247854,0.00002631126,0.00004563976,0.00003444965],"domain_scores_gemma":[0.9999533,0.00001062135,0.0000106137,0.000003302819,0.000009544955,0.00001265413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001880192,0.00005077016,0.0001772528,0.00004981942,0.00001687627,0.00002310913,0.000008636941,0.0001587869,0.9980069,0.00003441587,0.00006659795,0.001218882],"study_design_scores_gemma":[0.00002051508,0.0004318411,0.001698625,0.000002642279,0.0000172576,0.0001013741,0.000004737613,0.001337707,0.9949113,0.000007697618,0.001463764,0.000002529705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994554,0.002634739,0.001375838,0.00005920086,0.00002115416,0.00003005437,0.0001654637,0.00003655049,0.001123045],"genre_scores_gemma":[0.9955242,0.0009362269,0.001901171,0.00003218521,0.000008270001,0.00002337434,0.0003804708,0.000007230159,0.001186835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710236,"threshold_uncertainty_score":0.003400564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008901742072271845,"score_gpt":0.2327504001765731,"score_spread":0.2238486581043013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}