{"id":"W2063593425","doi":"10.1016/j.bmcl.2009.12.076","title":"3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: A lead tumor-specific cytotoxin which induces apoptosis and autophagy","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Morpholine; Apoptosis; Toxicity; DNA fragmentation; Autophagy; Cytotoxic T cell; Lead compound; Programmed cell death; Stereochemistry; Cytotoxicity; Caspase; In vitro; Cell culture; Fragmentation (computing); Biochemistry; Biology; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005100552,0.0008328633,0.001007454,0.00006673286,0.0003010503,0.0001343779,0.0009999865,0.0005021896,0.001922554],"category_scores_gemma":[0.0007956746,0.0006956841,0.0002136227,0.0005094982,0.0004915501,0.0001955193,0.0002450092,0.001058912,0.00003949303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924168,"about_ca_system_score_gemma":0.0001163654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007007614,"about_ca_topic_score_gemma":0.000001986234,"domain_scores_codex":[0.9958085,0.00006025732,0.0008239369,0.001455346,0.0008179758,0.001033924],"domain_scores_gemma":[0.9974585,0.00039581,0.0004183395,0.001092293,0.0001045558,0.0005305611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001748096,0.0002332899,0.0003507481,0.0001209895,0.00007337212,0.0001059408,0.0001400806,6.665732e-7,0.9942457,0.00001184825,0.00146795,0.003074586],"study_design_scores_gemma":[0.001050542,0.0000603193,0.001951726,0.0002190461,0.00009719538,0.0002552129,0.0004680897,0.00002920278,0.9914236,0.00005564919,0.003558077,0.0008313289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98677,0.001523597,0.00004004891,0.007764954,0.0001730596,0.0001440795,0.00003612514,0.0003433678,0.003204737],"genre_scores_gemma":[0.9945066,0.0003001131,0.0003628529,0.00247409,0.002025052,0.00003168918,0.00005792386,0.00005893315,0.0001827609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007736553,"threshold_uncertainty_score":0.9995494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579368637421112,"score_gpt":0.2191250806516711,"score_spread":0.20333139427746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}