{"id":"W2063593425","doi":"10.1016/j.bmcl.2009.12.076","title":"3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: A lead tumor-specific cytotoxin which induces apoptosis and autophagy","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Morpholine; Apoptosis; Toxicity; DNA fragmentation; Autophagy; Cytotoxic T cell; Lead compound; Programmed cell death; Stereochemistry; Cytotoxicity; Caspase; In vitro; Cell culture; Fragmentation (computing); Biochemistry; Biology; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247511,0.00029844,0.0002817943,0.0001937459,0.000167508,0.0001528339,0.0002668921,0.0002581838,0.001310267],"category_scores_gemma":[0.00008383112,0.0001124678,0.0001147387,0.000140842,0.000146904,0.0002191149,0.0001940797,0.000374139,0.0005772015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675137,"about_ca_system_score_gemma":0.000269765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003772468,"about_ca_topic_score_gemma":0.0006977172,"domain_scores_codex":[0.9999077,0.00001537674,0.000006736132,0.00001718871,0.00001917723,0.00003370251],"domain_scores_gemma":[0.9999474,0.000009594793,0.00001828951,0.000005820724,0.0000054659,0.00001339941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004016031,0.0000606104,0.000106228,0.0001447914,0.000007934773,0.0001990121,0.00003212287,0.0002751398,0.9900972,0.0007677822,0.0003780274,0.00752952],"study_design_scores_gemma":[0.0001154682,0.0009604339,0.001594317,0.000008530764,0.00001648611,0.0005041019,0.00001596373,0.0007582355,0.9899424,0.00008197733,0.005993405,0.000008657001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600058,0.006420061,0.01244383,0.0005039307,0.0002090874,0.0001102265,0.0009080949,0.0007935799,0.01860544],"genre_scores_gemma":[0.9929103,0.001349376,0.002452281,0.00005226574,0.00002542348,0.00004686482,0.0003212639,0.00001845802,0.002823735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310267,"threshold_uncertainty_score":0.004383266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579368637421112,"score_gpt":0.2191250806516711,"score_spread":0.20333139427746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}