{"id":"W2063598257","doi":"10.3109/08880018.2014.927945","title":"Predictive Performance of a Physiologically Based Pharmacokinetic Model of Busulfan in Children","year":2014,"lang":"en","type":"article","venue":"Pediatric Hematology and Oncology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre","funders":"","keywords":"Medicine; Pharmacokinetics; Busulfan; Pharmacology; Metabolic clearance rate; Oncology; Intensive care medicine; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007651643,0.0007763052,0.0005456692,0.0003795222,0.0001797539,0.0005749505,0.0005737142,0.0008291178,0.001142723],"category_scores_gemma":[0.002120987,0.000287352,0.000886842,0.0003129411,0.0002995555,0.000255632,0.0003775244,0.0008093956,0.000223036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000852059,"about_ca_system_score_gemma":0.001234904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02305165,"about_ca_topic_score_gemma":0.008331798,"domain_scores_codex":[0.9998277,0.00005626214,0.00001284477,0.0000493464,0.00002559247,0.00002808275],"domain_scores_gemma":[0.9990789,0.0006785201,0.00007226891,0.00003088691,0.0001076606,0.00003178366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000660981,0.000014169,0.00492879,0.00001799494,0.00001858021,0.00004724363,0.000009714221,0.9916127,0.0004284777,0.0001555655,0.0002673695,0.002433327],"study_design_scores_gemma":[0.0000161299,0.00005094356,0.002333528,0.00000837332,0.00001297124,0.00002933604,0.00001080123,0.9962451,0.0007390321,0.0002327648,0.0003144598,0.000006616322],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390013,0.0008240015,0.05256812,0.000479617,0.0000546651,0.00008840713,0.004302395,0.0005558034,0.002125746],"genre_scores_gemma":[0.9830683,0.0003008039,0.01216839,0.00009000464,0.00001562131,0.0001018619,0.003335274,0.0000457941,0.0008739633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02305165,"threshold_uncertainty_score":0.04583496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00944497255962832,"score_gpt":0.2592115748736104,"score_spread":0.2497666023139821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}