{"id":"W2063613219","doi":"10.2174/1381612054546798","title":"Targeting Central Plasticity: A New Direction of Finding Painkillers","year":2005,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; Canada Research Chairs","keywords":"Neuroscience; Spinal cord; Forebrain; Anterior cingulate cortex; Basal forebrain; Sensory system; Inhibitory postsynaptic potential; Central nervous system; Neuroplasticity; Glutamate receptor; Medicine; Biology; Cognition; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007013786,0.0007777157,0.001750887,0.001375235,0.0003086522,0.001228974,0.001050456,0.001366649,0.004014306],"category_scores_gemma":[0.000438319,0.0002484306,0.0005024208,0.00118469,0.0008473514,0.003003612,0.0006653157,0.002530476,0.002863758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006258156,"about_ca_system_score_gemma":0.0007077418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003919155,"about_ca_topic_score_gemma":0.0006928979,"domain_scores_codex":[0.9997639,0.00004283367,0.00002294989,0.00005162446,0.00009132786,0.00002740113],"domain_scores_gemma":[0.9998091,0.0000821486,0.00002452157,0.00001159245,0.00004691429,0.00002570564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001726662,0.0001839241,0.0001335949,0.01043012,0.00006919169,0.00039531,0.0001303179,0.0003734809,0.01770604,0.02187331,0.0206469,0.9278852],"study_design_scores_gemma":[0.00006353007,0.0003326316,0.0004341842,0.001391014,0.00006474998,0.00108617,0.00009339742,0.0001567197,0.002655496,0.009680928,0.9840183,0.00002305625],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004806223,0.9934865,0.001142828,0.001174861,0.0004023712,0.00001049624,0.00001556018,0.00002656876,0.003260131],"genre_scores_gemma":[0.002470493,0.9917783,0.001584052,0.001039347,0.0005412191,0.00001861478,0.00003169481,0.000007428156,0.002528787],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004014306,"threshold_uncertainty_score":0.01342922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2743960384244297,"score_gpt":0.4575495996567414,"score_spread":0.1831535612323117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}