{"id":"W2063635784","doi":"10.1074/jbc.m110.107623","title":"Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Messenger RNA; Molecular biology; Gene knockdown; Pertussis toxin; Transfection; Untranslated region; Chemistry; Luciferase; Small interfering RNA; Receptor; Signal transduction; MAPK/ERK pathway; Biology; Cell biology; Biochemistry; G protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407104,0.0003896285,0.0002487805,0.0004185823,0.0002749489,0.000478973,0.0001122186,0.0002589071,0.00210554],"category_scores_gemma":[0.0001463752,0.0001710513,0.0003206417,0.0001985511,0.0002556179,0.0002286109,0.0002065331,0.0004718819,0.001029127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005171083,"about_ca_system_score_gemma":0.0002949599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110405,"about_ca_topic_score_gemma":0.001421243,"domain_scores_codex":[0.9997932,0.00004117387,0.00001250789,0.0000390514,0.00004438857,0.00006968652],"domain_scores_gemma":[0.999911,0.000009236746,0.00003079829,0.000008518335,0.000016258,0.00002431999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191016,0.0000119043,0.0001622136,0.00001744864,0.00000275661,0.00003137904,0.000008811678,0.00002479514,0.9987679,0.00007708073,0.00002921843,0.0007474103],"study_design_scores_gemma":[0.00002496479,0.0002419685,0.01029484,0.000006409116,0.00002049369,0.0002426662,0.00006700807,0.0009471505,0.9845259,0.0001212985,0.003499902,0.00000733366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985423,0.00665366,0.004018751,0.0002798238,0.0000500674,0.00003239047,0.0006454941,0.0002086536,0.002688214],"genre_scores_gemma":[0.9899949,0.002356872,0.001589551,0.00006191507,0.00001835597,0.00003893114,0.0007016599,0.00001995747,0.005217906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00210554,"threshold_uncertainty_score":0.007043719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04590409403145146,"score_gpt":0.2724959138183783,"score_spread":0.2265918197869269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}