{"id":"W2063660456","doi":"10.1371/journal.pone.0084491","title":"Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Glycomics Centre; Canadian Blood Services; McMaster University","funders":"Health Canada; Heart and Stroke Foundation of Canada; Australian Government; Canadian Blood Services; McMaster University; Government of Canada","keywords":"Thrombin; Phage display; Serpin; Biotinylation; Molecular biology; Biopanning; Peptide library; Biology; Streptavidin; Bacteriophage; Biochemistry; Chemistry; Peptide sequence; Peptide; Escherichia coli; Biotin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817424,0.0002895402,0.0002665661,0.0001519649,0.0001345652,0.000347987,0.0002748784,0.0003204131,0.0006465649],"category_scores_gemma":[0.0001507765,0.0001378352,0.0002119169,0.0001757318,0.0001450735,0.00009004927,0.0001888401,0.0005015949,0.0002878826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226998,"about_ca_system_score_gemma":0.0001230726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005596973,"about_ca_topic_score_gemma":0.0008602303,"domain_scores_codex":[0.9997862,0.00003894691,0.0000131862,0.00003558132,0.00007370632,0.00005245705],"domain_scores_gemma":[0.9999329,0.00001499023,0.00001067374,0.000009461933,0.000009893331,0.00002205793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005892129,0.00001527992,0.00005014401,0.000008324545,0.000002847847,0.00002513126,0.000007104218,0.00006327261,0.9993883,0.00003554082,0.00002261224,0.0003224376],"study_design_scores_gemma":[0.00001362525,0.0001959283,0.001026883,0.000002248669,0.00001138762,0.0001202262,0.000008946829,0.001750493,0.9959027,0.00001609721,0.0009471089,0.000004261998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947202,0.000267359,0.003763557,0.00004164471,0.00001595687,0.00002950944,0.0001611802,0.0000702083,0.0009302424],"genre_scores_gemma":[0.9896451,0.0002020468,0.00653576,0.00006033848,0.000006507762,0.00003041989,0.0006014204,0.00002911324,0.002889323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006465649,"threshold_uncertainty_score":0.00234139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944555216287138,"score_gpt":0.2638131896915638,"score_spread":0.2343676375286924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}