{"id":"W2063665010","doi":"10.1080/10739680600930222","title":"The Role of K<sup>+</sup>Channels in Determining Pulmonary Vascular Tone, Oxygen Sensing, Cell Proliferation, and Apoptosis: Implications in Hypoxic Pulmonary Vasoconstriction and Pulmonary Arterial Hypertension","year":2006,"lang":"en","type":"review","venue":"Microcirculation","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Hypoxic pulmonary vasoconstriction; NADPH oxidase; Pulmonary hypertension; Inward-rectifier potassium ion channel; Calcium in biology; Voltage-dependent calcium channel; Depolarization; Chemistry; Cell biology; Biology; Reactive oxygen species; Intracellular; Vasoconstriction; Internal medicine; Calcium; Endocrinology; Biochemistry; Ion channel; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003929558,0.0003749401,0.0005547127,0.0003425197,0.0002426636,0.00006899802,0.00009893071,0.000586548,0.000001405044],"category_scores_gemma":[0.0000368738,0.0003400046,0.0001682229,0.0003701584,0.00009963558,0.00003378521,0.00009307951,0.0001974496,0.000001588179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008166183,"about_ca_system_score_gemma":0.0001274822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000648987,"about_ca_topic_score_gemma":0.000009401528,"domain_scores_codex":[0.9977224,0.0002883802,0.000886202,0.0006612249,0.0001596639,0.0002821429],"domain_scores_gemma":[0.9989902,0.0000615512,0.0004130916,0.0003362766,0.0001413196,0.00005758692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004406491,0.0001844199,0.001929239,0.001068265,0.0000541674,0.000003669044,0.00009984511,0.002090959,0.06232487,0.00002042966,0.00004402399,0.9321361],"study_design_scores_gemma":[0.002251469,0.0002887604,0.01651171,0.004419159,0.001055739,0.001637596,0.001181939,0.1970673,0.009125059,0.001294713,0.7623525,0.002814001],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1842481,0.8126531,0.0007451583,0.00004036408,0.0002391729,0.00179932,0.00003616949,0.00002463754,0.0002139765],"genre_scores_gemma":[0.5020134,0.4956148,0.000119518,0.00002086283,0.0004345171,0.0001236122,0.001560179,0.00005601857,0.00005711161],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9293221,"threshold_uncertainty_score":0.9999052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396272757412989,"score_gpt":0.2400374001221451,"score_spread":0.2260746725480152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}