{"id":"W2063665010","doi":"10.1080/10739680600930222","title":"The Role of K<sup>+</sup>Channels in Determining Pulmonary Vascular Tone, Oxygen Sensing, Cell Proliferation, and Apoptosis: Implications in Hypoxic Pulmonary Vasoconstriction and Pulmonary Arterial Hypertension","year":2006,"lang":"en","type":"review","venue":"Microcirculation","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Hypoxic pulmonary vasoconstriction; NADPH oxidase; Pulmonary hypertension; Inward-rectifier potassium ion channel; Calcium in biology; Voltage-dependent calcium channel; Depolarization; Chemistry; Cell biology; Biology; Reactive oxygen species; Intracellular; Vasoconstriction; Internal medicine; Calcium; Endocrinology; Biochemistry; Ion channel; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003892348,0.0003970391,0.0004207284,0.0002690961,0.0002436623,0.001061035,0.0005397024,0.0007004595,0.0009652941],"category_scores_gemma":[0.0003987595,0.0001782948,0.0002145436,0.0002043344,0.001026078,0.001614222,0.0004877825,0.0006966584,0.0003343337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668487,"about_ca_system_score_gemma":0.0003211204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002966651,"about_ca_topic_score_gemma":0.0002853367,"domain_scores_codex":[0.9998547,0.00002865568,0.00002123926,0.00002545242,0.0000330951,0.00003681575],"domain_scores_gemma":[0.9996138,0.00008801341,0.0001287692,0.00001842361,0.00005664901,0.00009438283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004407085,0.0002506622,0.01926333,0.00295162,0.0001104792,0.003474344,0.0006735048,0.001562111,0.7496274,0.03155147,0.004308043,0.18182],"study_design_scores_gemma":[0.0003354782,0.005029493,0.2782113,0.0009584776,0.0004760218,0.01991839,0.003164064,0.01351822,0.4601216,0.06603225,0.1520083,0.000226418],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.457247,0.5039988,0.01753834,0.009503528,0.0008497762,0.00005071094,0.0004056784,0.0002438949,0.01016224],"genre_scores_gemma":[0.8768094,0.114278,0.003025179,0.0009460734,0.0005824324,0.0000406068,0.0001657469,0.00002347545,0.004129251],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001061035,"threshold_uncertainty_score":0.003387272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396272757412989,"score_gpt":0.2400374001221451,"score_spread":0.2260746725480152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}