{"id":"W2063676577","doi":"10.1182/blood-2008-04-151191","title":"A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Gene silencing; In vivo; Small interfering RNA; Immune system; Dendritic cell; CD40; RNA interference; Cell biology; Biology; In vitro; Chemistry; Immunology; RNA; Gene; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002862462,0.000493945,0.0004181889,0.0003467468,0.0002512814,0.0003739054,0.0003044144,0.0005578522,0.0009837],"category_scores_gemma":[0.0001397849,0.0002430309,0.0002720737,0.000116012,0.0002647253,0.000317688,0.0002368217,0.0007148358,0.0005457675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011195,"about_ca_system_score_gemma":0.0004590004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004540836,"about_ca_topic_score_gemma":0.0005769276,"domain_scores_codex":[0.9998143,0.00002746991,0.000020526,0.00005238009,0.00005679161,0.00002862959],"domain_scores_gemma":[0.9999114,0.00001466192,0.0000226521,0.00001077885,0.00001616843,0.00002422027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002723335,0.00002291778,0.00002510838,0.00003294249,0.000002769556,0.00003097138,0.000009628042,0.00003053075,0.9973468,0.0001305667,0.00006723998,0.002273304],"study_design_scores_gemma":[0.00002044173,0.0002654612,0.0002348599,0.000001980856,0.00002023238,0.0003153958,0.00000317726,0.0006863715,0.9938444,0.00002280944,0.004579684,0.000005191785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7747748,0.006743943,0.2065237,0.001202897,0.0004910878,0.0006616148,0.0009672422,0.001543994,0.007090766],"genre_scores_gemma":[0.8638005,0.003523954,0.117829,0.000427449,0.0001288451,0.0004741225,0.001265293,0.0001359584,0.01241495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009837,"threshold_uncertainty_score":0.003290772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009926413132230853,"score_gpt":0.2131201188410189,"score_spread":0.203193705708788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}