{"id":"W2063676577","doi":"10.1182/blood-2008-04-151191","title":"A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Gene silencing; In vivo; Small interfering RNA; Immune system; Dendritic cell; CD40; RNA interference; Cell biology; Biology; In vitro; Chemistry; Immunology; RNA; Gene; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313076,0.0001226596,0.0001329048,0.00004742437,0.00005871333,0.00003469964,0.00009445631,0.0001075679,0.000002225981],"category_scores_gemma":[0.00001995352,0.0001263636,0.00005662813,0.00004299159,0.00001554192,0.000007457603,0.00002802026,0.00004375847,0.000001769345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001186687,"about_ca_system_score_gemma":0.00002672988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002437782,"about_ca_topic_score_gemma":0.00001759001,"domain_scores_codex":[0.9991829,0.0000171489,0.0002389229,0.0002896605,0.00006366438,0.0002077465],"domain_scores_gemma":[0.9996738,0.0000151804,0.0000602119,0.0001379666,0.0000741495,0.00003862993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004665727,0.00008922009,0.0004248625,0.00003545821,0.00001777337,0.000004013351,0.00004571084,0.0001186973,0.9978514,0.00002996155,0.00004969121,0.001286592],"study_design_scores_gemma":[0.00106418,0.0003342843,0.002986704,0.00007746315,0.0000276642,0.00002591578,0.0003096274,0.0008598983,0.993894,0.00001371267,0.0002276915,0.0001788512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937366,0.001807636,0.003950451,0.00001761091,0.00009291778,0.0002049958,0.00002290788,0.00001106554,0.000155872],"genre_scores_gemma":[0.996123,0.0001635119,0.003313914,0.00006528696,0.0002236711,0.00001291219,0.0000249849,0.00001119129,0.00006149178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003957355,"threshold_uncertainty_score":0.5152957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009926413132230853,"score_gpt":0.2131201188410189,"score_spread":0.203193705708788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}