{"id":"W2063682360","doi":"10.1016/j.bmc.2008.03.060","title":"1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Aryl; Cytotoxicity; Stereochemistry; Cytotoxic T cell; Adduct; Hydroxymethyl; Apoptosis; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005791686,0.0004687909,0.0007660248,0.00003174831,0.0004221025,0.00002389549,0.000356568,0.0005661814,0.0007236334],"category_scores_gemma":[0.001270431,0.0003679771,0.0001968938,0.0001965481,0.0005078546,0.00009833353,0.0001203416,0.0004367501,0.00001159412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914569,"about_ca_system_score_gemma":0.0001734028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004188416,"about_ca_topic_score_gemma":0.000002599307,"domain_scores_codex":[0.9974535,0.0000255497,0.0005710077,0.0009833664,0.0003063369,0.0006601993],"domain_scores_gemma":[0.9977872,0.0009675598,0.0003288288,0.0003848325,0.0002109442,0.0003206045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004281427,0.0003573191,0.0004929896,0.0005660314,0.0001790517,0.0000185113,0.0001219357,9.657058e-8,0.9960963,0.00001064287,0.0007125083,0.001016525],"study_design_scores_gemma":[0.00155867,0.0002032543,0.0008312479,0.0001498268,0.0001655227,0.0002047673,0.0002345613,0.00005788,0.9940999,0.0005529058,0.001430148,0.0005113849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945117,0.001556058,0.0001284865,0.0003306725,0.00009240576,0.0004484714,0.0002586191,0.0001724354,0.002501199],"genre_scores_gemma":[0.9959692,0.0003775147,0.0007675781,0.00009295815,0.0006782378,0.0001966891,0.0001039051,0.00005786927,0.001756039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996415,"threshold_uncertainty_score":0.9998772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046899101222458,"score_gpt":0.2316327616531657,"score_spread":0.2011637706409411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}