{"id":"W2063692415","doi":"10.1074/jbc.m202256200","title":"The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"DNA demethylation; Cancer epigenetics; DNA methylation; Histone methyltransferase; Trichostatin A; Histone acetyltransferase; Histone; Histone H2A; Histone methylation; HDAC11; Biology; Histone code; Molecular biology; Epigenetics; Epigenomics; Epigenetics of physical exercise; Histone deacetylase; Genetics; DNA; Gene expression; Gene; Nucleosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008024342,0.000157932,0.0002717786,0.00003210738,0.0001011354,0.00001381767,0.0001415048,0.000285144,0.00003033847],"category_scores_gemma":[0.0004865365,0.0001080076,0.0001453946,0.0001070977,0.0002106713,0.00002027152,0.00002506704,0.0002317871,1.520511e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003451426,"about_ca_system_score_gemma":0.0000460538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006325062,"about_ca_topic_score_gemma":0.000006464767,"domain_scores_codex":[0.9985339,0.0001574911,0.0007192162,0.0001967186,0.0002348549,0.0001578378],"domain_scores_gemma":[0.9987165,0.000113261,0.0005820884,0.0001362693,0.0003556393,0.00009628911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001853535,0.00008182379,0.0004245914,0.00003022273,0.00004447465,4.995607e-7,0.0002364585,0.00009839294,0.9813446,0.00002410309,0.000006430625,0.01752303],"study_design_scores_gemma":[0.0005397846,0.000698036,0.002466918,0.00005265962,0.00002710562,0.00001050454,0.0003919631,0.000187007,0.9948676,0.0003178555,0.000323737,0.0001168294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904109,0.00527446,0.003820063,0.0001177045,0.00006781924,0.0001073216,0.00002918256,0.000003029526,0.0001695157],"genre_scores_gemma":[0.9967019,0.001359414,0.001586098,0.00001153184,0.0002601135,0.000003424979,0.0000379973,0.000009641499,0.00002987258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0174062,"threshold_uncertainty_score":0.4404423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02974314716819062,"score_gpt":0.2884299555228644,"score_spread":0.2586868083546738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}