{"id":"W2063692415","doi":"10.1074/jbc.m202256200","title":"The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"DNA demethylation; Cancer epigenetics; DNA methylation; Histone methyltransferase; Trichostatin A; Histone acetyltransferase; Histone; Histone H2A; Histone methylation; HDAC11; Biology; Histone code; Molecular biology; Epigenetics; Epigenomics; Epigenetics of physical exercise; Histone deacetylase; Genetics; DNA; Gene expression; Gene; Nucleosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008464928,0.0004704731,0.0002049776,0.0003297664,0.0001272408,0.0002339301,0.000208954,0.0001328207,0.0008318737],"category_scores_gemma":[0.00007417442,0.0001512274,0.0002863573,0.0001654326,0.000203888,0.00009986421,0.0001558905,0.000492157,0.0003534868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604691,"about_ca_system_score_gemma":0.0001972439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992863,"about_ca_topic_score_gemma":0.00101489,"domain_scores_codex":[0.9999143,0.000007404214,0.000006860237,0.00001411011,0.00003345124,0.0000238024],"domain_scores_gemma":[0.9999473,0.000005266706,0.00001907563,0.000007039959,0.000004310646,0.00001703885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004202633,0.00001420184,0.0002267748,0.0000236711,0.00001151787,0.00002769898,0.00000345856,0.00003439963,0.9978557,0.0001041964,0.0000602062,0.001596063],"study_design_scores_gemma":[0.00001882191,0.0001654996,0.003232789,0.000004922618,0.00002372175,0.000392838,0.00000925699,0.0005422875,0.9911382,0.00006264522,0.004406705,0.000002387446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755563,0.01095498,0.008078871,0.0002102927,0.0001059441,0.00004715439,0.0006209456,0.0003431469,0.004082377],"genre_scores_gemma":[0.9894893,0.003689532,0.002333362,0.00006090591,0.00001623844,0.00003873923,0.001028139,0.00002553065,0.003318241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008318737,"threshold_uncertainty_score":0.002782881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02974314716819062,"score_gpt":0.2884299555228644,"score_spread":0.2586868083546738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}