{"id":"W2063710448","doi":"10.3390/molecules20047222","title":"Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex","year":2015,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; University of Oklahoma; Ryerson University; Oklahoma State University; W. M. Keck Foundation","keywords":"Bacillus anthracis; Pincer movement; Combinatorial chemistry; Chemistry; Triethylamine; Piperidine; Enantiomer; Catalysis; Enantiomeric excess; Base (topology); Stereochemistry; Organic chemistry; Enantioselective synthesis; Biology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003447932,0.0005715188,0.0005050318,0.0004044782,0.0001511409,0.0003634499,0.0004629082,0.0003824709,0.001006693],"category_scores_gemma":[0.0002416292,0.0002251854,0.0002044398,0.000252676,0.0002821217,0.0003227164,0.0003495167,0.0004833471,0.0003517705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230318,"about_ca_system_score_gemma":0.0002775884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004578605,"about_ca_topic_score_gemma":0.00115291,"domain_scores_codex":[0.9997769,0.00005299656,0.00002257655,0.00004119692,0.00006747702,0.00003898788],"domain_scores_gemma":[0.9998716,0.0000223144,0.0000323956,0.00001435388,0.00001925396,0.00003997871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000137072,0.00006871672,0.00008528942,0.0001497616,0.00001321943,0.0001045414,0.00003634921,0.0005786973,0.9930576,0.0001351018,0.00005059557,0.005582923],"study_design_scores_gemma":[0.00006368636,0.001625648,0.0005962278,0.000008676791,0.00003114351,0.0003155677,0.00001407061,0.0005003829,0.9932564,0.00002452131,0.003553287,0.0000103153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792644,0.00774322,0.007871664,0.0001275726,0.00004468079,0.0003774653,0.0005628901,0.0001631582,0.003844943],"genre_scores_gemma":[0.9794087,0.005607135,0.01156655,0.00006135379,0.00002024307,0.0001289235,0.0007255778,0.00002400393,0.002457619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006693,"threshold_uncertainty_score":0.003367722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2976404185526205,"score_gpt":0.3632861844732994,"score_spread":0.06564576592067894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}