{"id":"W2063726626","doi":"10.1007/s10495-007-0175-4","title":"A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization","year":2008,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Nuclear localization sequence; Subcellular localization; Transactivation; Cytoplasm; Nuclear transport; Cell biology; Nucleus; Cell nucleus; Cell cycle; DNA; Apoptosis; DNA damage; NLS; Chemistry; Function (biology); Nuclear export signal; Nuclear protein; Biology; Mutant; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385838,0.0003704394,0.0002900886,0.0005417146,0.0002809415,0.0001954423,0.0002410951,0.0004395086,0.002416467],"category_scores_gemma":[0.0001325515,0.0001652825,0.0002092114,0.000217884,0.0001979485,0.0001531045,0.0002004937,0.0002807073,0.0002735106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381061,"about_ca_system_score_gemma":0.0001534159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006455622,"about_ca_topic_score_gemma":0.001450683,"domain_scores_codex":[0.9999176,0.00001713541,0.000005372328,0.00001578657,0.00002456266,0.00001953937],"domain_scores_gemma":[0.999903,0.00003305761,0.00001930539,0.000008772302,0.00001490802,0.00002093764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004492869,0.00008877761,0.0003550488,0.00004474841,0.00001912929,0.0001618224,0.00001050326,0.000173678,0.9957693,0.00005503377,0.00006693028,0.002805877],"study_design_scores_gemma":[0.00005657654,0.0008561294,0.001624684,0.00000425296,0.0000322973,0.0002221565,0.00001230515,0.000284227,0.9958619,0.00002076693,0.001020446,0.000004232825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926404,0.001394501,0.002747981,0.000178485,0.00002276804,0.000100273,0.0004925226,0.0001010216,0.002321971],"genre_scores_gemma":[0.9938921,0.0009679041,0.001610148,0.00008195234,0.000007782728,0.00002191792,0.0004573695,0.00001249267,0.002948453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002416467,"threshold_uncertainty_score":0.00808388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472094678771083,"score_gpt":0.232101315642867,"score_spread":0.2073803688551561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}