{"id":"W2063753138","doi":"10.1016/s0024-3205(03)00093-6","title":"Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6","year":2003,"lang":"en","type":"article","venue":"Life Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Alpha (finance); Albumin; Glycoprotein; Alpha globulin; Globulin; Gamma globulin; Biochemistry; Microsome; Serum albumin; Chemistry; Gene isoform; Pharmacology; Biology; In vitro; Endocrinology; Immunology; Medicine; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009311067,0.0003341682,0.000515371,0.0003366768,0.0003855005,0.00003417991,0.0002014397,0.0001977361,0.00006281477],"category_scores_gemma":[0.0001088761,0.0002630585,0.00004592428,0.000390319,0.00143832,0.0002942391,0.0001159548,0.0004504987,0.000002387827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002472038,"about_ca_system_score_gemma":0.0001156134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001197768,"about_ca_topic_score_gemma":0.0001555806,"domain_scores_codex":[0.9978144,0.0003390276,0.0005287182,0.0005696777,0.0002915817,0.0004566445],"domain_scores_gemma":[0.998912,0.0001843873,0.0003736815,0.000165198,0.00008026637,0.00028441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003355002,0.0007303652,0.0642283,0.0006780304,0.0001031402,0.0000444697,0.002620223,0.00004880837,0.9249895,0.00177851,0.0001107565,0.004332353],"study_design_scores_gemma":[0.003659704,0.00261928,0.03988193,0.000239731,0.0001125269,0.00004679814,0.0005163857,0.000249577,0.9492565,0.0003849046,0.002667488,0.0003651754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912269,0.006253508,0.00001428253,0.0001416494,0.0003030381,0.001012425,0.00004450343,0.00002210886,0.0009816306],"genre_scores_gemma":[0.9972041,0.001625355,0.0004034449,0.0005203653,0.00008673777,0.00005322937,0.000003570312,0.00001892799,0.00008430379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02434636,"threshold_uncertainty_score":0.9999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04460263588564069,"score_gpt":0.3697781050918095,"score_spread":0.3251754692061689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}