{"id":"W2063753138","doi":"10.1016/s0024-3205(03)00093-6","title":"Interaction of serum proteins with CYP isoforms in human liver microsomes: inhibitory effects of human and bovine albumin, alpha-globulins, alpha-1-acid glycoproteins and gamma-globulins on CYP2C19 and CYP2D6","year":2003,"lang":"en","type":"article","venue":"Life Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Alpha (finance); Albumin; Glycoprotein; Alpha globulin; Globulin; Gamma globulin; Biochemistry; Microsome; Serum albumin; Chemistry; Gene isoform; Pharmacology; Biology; In vitro; Endocrinology; Immunology; Medicine; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007664859,0.0007196626,0.0006017952,0.0002430838,0.0002955818,0.0003451336,0.0002514731,0.0003774222,0.001422038],"category_scores_gemma":[0.0009598964,0.0002504832,0.0006241885,0.0004945594,0.0002779321,0.0002121562,0.0002663313,0.0004441191,0.0004585375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005297887,"about_ca_system_score_gemma":0.0004382808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003787623,"about_ca_topic_score_gemma":0.004293827,"domain_scores_codex":[0.9994897,0.000276523,0.00003744113,0.00004849708,0.00005793014,0.00008997632],"domain_scores_gemma":[0.9997106,0.000124621,0.00004317863,0.00003297814,0.0000505132,0.00003804575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007196514,0.0003933567,0.00314267,0.0003837787,0.0002498973,0.0002848546,0.000223967,0.0009778003,0.9754785,0.0002568328,0.0007600251,0.01065182],"study_design_scores_gemma":[0.0001603294,0.001315702,0.008664282,0.00001800414,0.0001129969,0.0003904127,0.00005125529,0.00195623,0.9847528,0.00004923808,0.002516739,0.00001194921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903161,0.005514988,0.002655143,0.0002397096,0.00009155021,0.0000430246,0.0003137265,0.00006648502,0.0007592788],"genre_scores_gemma":[0.992776,0.001756908,0.00227016,0.0001162731,0.00005796424,0.00003987473,0.001308245,0.0000295696,0.00164496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003787623,"threshold_uncertainty_score":0.007531166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04460263588564069,"score_gpt":0.3697781050918095,"score_spread":0.3251754692061689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}