{"id":"W2063756018","doi":"10.1158/0008-5472.sabcs11-p3-16-01","title":"P3-16-01: Safety Profile and Clinical Activity of Single-Agent BKM120, a Pan-Class I PI3K Inhibitor, for the Treatment of Patients with Metastatic Breast Carcinoma.","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Breast cancer; Adverse effect; Gastroenterology; Metastatic breast cancer; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000515746,0.0001925214,0.0005628458,0.0001060562,0.0001201463,0.000007046465,0.0001281001,0.00005851504,0.0001484659],"category_scores_gemma":[0.00006372654,0.0001092227,0.0001211927,0.0002824244,0.0009256686,0.00009407778,0.00005611237,0.0001913997,0.000001351636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005821742,"about_ca_system_score_gemma":0.0004787059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077922,"about_ca_topic_score_gemma":0.0003827787,"domain_scores_codex":[0.9979846,0.0002015122,0.0004000668,0.0003970267,0.0005914989,0.0004253158],"domain_scores_gemma":[0.9977903,0.0006299391,0.0002024881,0.0005103247,0.0007019507,0.000165013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04970901,0.004986425,0.2839204,0.0006331358,0.001156805,0.000007319444,0.002618396,0.000002100454,0.005678876,0.00005752355,0.0001103233,0.6511197],"study_design_scores_gemma":[0.01727916,0.01688466,0.8900426,0.0003497566,0.0005076271,0.00001229529,0.0009432242,0.00007369209,0.0683413,0.0001082891,0.005241106,0.0002163116],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939194,0.001540029,0.0005341687,0.0003391702,0.00009998387,0.002811324,0.0005971157,0.00001252667,0.0001462559],"genre_scores_gemma":[0.9977798,0.0003283454,0.0008771156,0.00001882935,0.0001156982,0.0005567015,0.00001820886,0.00004251802,0.0002627351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6509034,"threshold_uncertainty_score":0.4453972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1623529300358657,"score_gpt":0.4113457694450203,"score_spread":0.2489928394091546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}