{"id":"W2063764327","doi":"10.1186/1742-4690-11-45","title":"HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"School of Medicine, Indiana University; Center for AIDS Research, University of Washington; Higher Education Discipline Innovation Project; National Institutes of Health; Keio University; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Directorate for Biological Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Gene knockdown; Phosphorylation; Cell biology; Activator (genetics); Mutant; Transcription factor; Ubiquitin ligase; Ubiquitin; Signal transduction; Kinase; NF-κB; NFKB1; IκB kinase; Biology; Gene; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003650291,0.000187094,0.0002380682,0.00006426434,0.00007108803,0.00001846496,0.0001568839,0.0002928085,0.00002476942],"category_scores_gemma":[0.0003062005,0.0001916657,0.0000441064,0.00007157925,0.0001161533,0.00000459944,0.0001225896,0.0001940837,0.00001403556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001445695,"about_ca_system_score_gemma":0.00002271556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002600879,"about_ca_topic_score_gemma":0.000006854792,"domain_scores_codex":[0.9986534,0.0001563694,0.0002388264,0.0004797028,0.00008738574,0.0003842886],"domain_scores_gemma":[0.9994208,0.0001019728,0.0001033163,0.0002636846,0.00002865186,0.00008155492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000561649,0.00002492301,0.02907897,0.00001501678,0.00001769411,0.000002733525,0.0000412986,0.000376114,0.9680843,0.00009394951,0.0004664947,0.001742386],"study_design_scores_gemma":[0.001293644,0.0007134178,0.002571815,0.00002055742,0.00001465047,0.00002985942,0.00003787663,0.002872086,0.9755296,0.0003345996,0.01621575,0.0003661106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944267,0.0005058381,0.004147512,0.0002056626,0.00007761765,0.0001002824,0.00001255992,0.00002297013,0.0005008454],"genre_scores_gemma":[0.9977002,0.00003129461,0.001205456,0.0005344052,0.0001926516,0.00001070672,0.000091406,0.00003420584,0.0001996597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02650716,"threshold_uncertainty_score":0.7815902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004927175682872586,"score_gpt":0.208955850062912,"score_spread":0.2040286743800394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}