{"id":"W2063764327","doi":"10.1186/1742-4690-11-45","title":"HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1","year":2014,"lang":"en","type":"article","venue":"Retrovirology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"School of Medicine, Indiana University; Center for AIDS Research, University of Washington; Higher Education Discipline Innovation Project; National Institutes of Health; Keio University; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Directorate for Biological Sciences; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Gene knockdown; Phosphorylation; Cell biology; Activator (genetics); Mutant; Transcription factor; Ubiquitin ligase; Ubiquitin; Signal transduction; Kinase; NF-κB; NFKB1; IκB kinase; Biology; Gene; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001805389,0.0005268204,0.0002162701,0.0002684637,0.0002044461,0.0003139749,0.0002301143,0.0002681807,0.003663366],"category_scores_gemma":[0.0001131436,0.000143094,0.0005139053,0.0001222275,0.0002255238,0.0002876658,0.0002644561,0.0008616093,0.000822663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671153,"about_ca_system_score_gemma":0.0001415361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000141099,"about_ca_topic_score_gemma":0.0001728243,"domain_scores_codex":[0.9998128,0.00003607363,0.00001728951,0.00003157899,0.0000485784,0.00005367737],"domain_scores_gemma":[0.9999082,0.00001381419,0.00002710281,0.00001093514,0.00001149929,0.00002857131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000225639,0.000072896,0.0002050441,0.0001800426,0.00001269631,0.00008192448,0.00002092385,0.00008847612,0.996857,0.000141552,0.0001418179,0.001971846],"study_design_scores_gemma":[0.00006821312,0.0005212203,0.00555027,0.00004249553,0.0000429203,0.0006723895,0.00006937605,0.001807654,0.9855176,0.0002535056,0.005444393,0.00001005079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822113,0.008043914,0.004204117,0.0003133426,0.0001899157,0.00004531645,0.0006014733,0.0001484817,0.004242118],"genre_scores_gemma":[0.992178,0.001931951,0.002954556,0.00009239246,0.00004178868,0.00004355878,0.0006971196,0.00001780279,0.002042915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003663366,"threshold_uncertainty_score":0.01225519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004927175682872586,"score_gpt":0.208955850062912,"score_spread":0.2040286743800394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}