{"id":"W2063774385","doi":"10.1016/j.bcp.2005.10.052","title":"Dihydrofolate reductase inhibitors as antibacterial agents","year":2005,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":335,"is_retracted":false,"has_abstract":false,"ca_institutions":"Adidas (Canada)","funders":"","keywords":"Dihydrofolate reductase; Antibiotics; Trimethoprim; Antibacterial activity; Antibacterial agent; Chemistry; Biology; Microbiology; Bacteria; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001037083,0.000727443,0.00207494,0.0002947204,0.00008481416,0.00002226889,0.0002046396,0.0008417189,0.002359413],"category_scores_gemma":[0.00006027903,0.0005900648,0.000864164,0.0003292458,0.0001809242,0.00004291283,0.0001787223,0.0008018455,0.002599336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006207722,"about_ca_system_score_gemma":0.0004342351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008494099,"about_ca_topic_score_gemma":5.434819e-8,"domain_scores_codex":[0.9971644,0.0001695038,0.0008844195,0.0008859391,0.0002811653,0.0006145587],"domain_scores_gemma":[0.9985072,0.00008724042,0.0003638864,0.0003584558,0.00005297803,0.0006302661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003912095,0.001504405,9.453438e-7,0.004556009,0.001800349,0.001665378,0.0000171567,6.962789e-8,0.09129009,0.000007032947,0.334313,0.5644543],"study_design_scores_gemma":[0.001958897,0.0003013807,0.00000182316,0.001329367,0.004319854,0.002295317,8.842516e-7,0.000002524989,0.01452819,0.000003282714,0.9748294,0.0004290718],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01133537,0.9820742,3.490516e-7,0.0003333449,0.003443445,0.001498437,0.0001104554,0.0002182892,0.0009861243],"genre_scores_gemma":[0.003731104,0.9890797,0.00005134231,0.0006766216,0.003974197,0.0002159866,0.0006223543,0.0001162217,0.001532483],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6405164,"threshold_uncertainty_score":0.9996551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540721703765624,"score_gpt":0.405491637830235,"score_spread":0.3600844207925787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}