{"id":"W2063774385","doi":"10.1016/j.bcp.2005.10.052","title":"Dihydrofolate reductase inhibitors as antibacterial agents","year":2005,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":335,"is_retracted":false,"has_abstract":false,"ca_institutions":"Adidas (Canada)","funders":"","keywords":"Dihydrofolate reductase; Antibiotics; Trimethoprim; Antibacterial activity; Antibacterial agent; Chemistry; Biology; Microbiology; Bacteria; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006203661,0.001264162,0.002401093,0.003127339,0.0002442494,0.0008483491,0.0009477436,0.001079978,0.003719902],"category_scores_gemma":[0.000657174,0.0003959917,0.0004986554,0.002262341,0.000409115,0.00113764,0.0005092671,0.001573518,0.002174119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004947518,"about_ca_system_score_gemma":0.0009482558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009235343,"about_ca_topic_score_gemma":0.00266698,"domain_scores_codex":[0.9997776,0.00003484649,0.00004561122,0.0000344436,0.00008505677,0.00002241596],"domain_scores_gemma":[0.9996371,0.0001343751,0.00009272839,0.00001290325,0.00008801924,0.00003475922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001733637,0.0001623259,0.0001611812,0.01452393,0.000120261,0.0002798529,0.00003799295,0.0002497154,0.003724805,0.0008773601,0.01685113,0.9628381],"study_design_scores_gemma":[0.0001218112,0.0005099013,0.001581728,0.003497386,0.000521064,0.002392982,0.0000561166,0.0001892325,0.00235039,0.0007113693,0.9880391,0.00002906794],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001996298,0.9983298,0.0001818328,0.0001239669,0.0001795738,0.000009249886,0.00002086736,0.00001148237,0.0009435585],"genre_scores_gemma":[0.001368175,0.9968246,0.0003236068,0.0001744749,0.0002120499,0.00001039747,0.00004100349,0.000001546681,0.001044287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003719902,"threshold_uncertainty_score":0.01244432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540721703765624,"score_gpt":0.405491637830235,"score_spread":0.3600844207925787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}