{"id":"W2063795609","doi":"10.1016/s0167-4838(00)00286-7","title":"Ca 2+ -induced structural changes in rat m -calpain revealed by partial proteolysis","year":2001,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Proteolysis; Calpain; Proteases; Cleavage (geology); Trypsin; Protease; Active site; Chymotrypsin; Chemistry; Protein subunit; Biochemistry; Conformational change; Enzyme; Mutant; Serine protease; Binding site; Biophysics; Peptide; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002564694,0.0004939698,0.000316455,0.0003305751,0.0002467017,0.000313447,0.0004878869,0.0003695308,0.001186663],"category_scores_gemma":[0.0004076642,0.000435934,0.0004983458,0.0003893625,0.000474117,0.0005322972,0.0002208697,0.0006972044,0.0003809531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261238,"about_ca_system_score_gemma":0.0002040116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00076725,"about_ca_topic_score_gemma":0.000972071,"domain_scores_codex":[0.9998844,0.00002002253,0.00001222294,0.0000215271,0.00002100491,0.00004081185],"domain_scores_gemma":[0.9997143,0.00007432533,0.00009362703,0.00004947382,0.00003416118,0.00003393761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001036437,0.00003554328,0.0003075523,0.00006787162,0.00001580762,0.0001573708,0.00002928912,0.00007114336,0.9971271,0.0001331601,0.00003279588,0.0009859538],"study_design_scores_gemma":[0.00005472072,0.0003674273,0.01293185,0.000007194176,0.00003724838,0.0006496955,0.00003779525,0.0005876864,0.9844333,0.0001141273,0.000771453,0.000007681626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932099,0.003049065,0.001879134,0.0001012923,0.00002386478,0.00002344819,0.0003284838,0.00004307282,0.001341711],"genre_scores_gemma":[0.9946948,0.001455892,0.001506841,0.00006500531,0.00002400469,0.00003298128,0.000879414,0.00002277177,0.001318402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186663,"threshold_uncertainty_score":0.003969789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005792351922173505,"score_gpt":0.2327924877214974,"score_spread":0.2270001357993238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}