{"id":"W2063816713","doi":"10.1038/sj.cr.7310060","title":"Proteomic identification of potential target proteins regulated by an ASK1-mediated proteolysis pathway","year":2006,"lang":"en","type":"article","venue":"Cell Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Fudan University; Pennsylvania State University; National Science Foundation","keywords":"Biology; Arabidopsis; Ubiquitin ligase; Skp1; Cell biology; Proteolysis; F-box protein; Cullin; Mutant; Proteome; ASK1; Gene; Ubiquitin; Molecular biology; Genetics; Biochemistry; Cell cycle; Cyclin-dependent kinase 2; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001592281,0.0001735137,0.000182273,0.0001598728,0.0001924676,0.00006402059,0.0004499452,0.0003042808,0.000119624],"category_scores_gemma":[0.0001233559,0.0001691983,0.00009193167,0.0003991998,0.0002490002,0.00001312199,0.0001453509,0.0002734433,0.00005875681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003164069,"about_ca_system_score_gemma":0.0002514373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002452334,"about_ca_topic_score_gemma":0.000009427348,"domain_scores_codex":[0.9972642,0.0005513595,0.000462905,0.0005867278,0.0006119519,0.0005228769],"domain_scores_gemma":[0.9984438,0.00001056507,0.0001776102,0.0006856254,0.0005502793,0.0001321278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001776665,0.0004003212,0.0002711797,0.00009518373,0.00001440356,0.000003719614,0.00003058397,0.00006194862,0.9964407,0.00002031319,0.001875224,0.0006087369],"study_design_scores_gemma":[0.0005753962,0.0005173626,0.0009514362,0.00001202757,0.000004888096,0.000002617415,0.00003280855,0.0005888978,0.9926599,0.0003917852,0.004078752,0.000184111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993641,0.0003410874,0.002060512,0.00009133507,0.00003668388,0.002190373,0.0001920272,0.00002855937,0.001418468],"genre_scores_gemma":[0.9901309,0.00002627451,0.0008396624,0.00000784977,0.0001955055,0.0005379193,0.002086615,0.00004504092,0.006130249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00471178,"threshold_uncertainty_score":0.6899707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497464397020827,"score_gpt":0.2740643205970354,"score_spread":0.2590896766268271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}