{"id":"W2063816713","doi":"10.1038/sj.cr.7310060","title":"Proteomic identification of potential target proteins regulated by an ASK1-mediated proteolysis pathway","year":2006,"lang":"en","type":"article","venue":"Cell Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Fudan University; Pennsylvania State University; National Science Foundation","keywords":"Biology; Arabidopsis; Ubiquitin ligase; Skp1; Cell biology; Proteolysis; F-box protein; Cullin; Mutant; Proteome; ASK1; Gene; Ubiquitin; Molecular biology; Genetics; Biochemistry; Cell cycle; Cyclin-dependent kinase 2; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003399074,0.00057142,0.0005130991,0.0006033729,0.0005242334,0.0005795675,0.0003057573,0.0003547778,0.001671973],"category_scores_gemma":[0.000303313,0.0001908741,0.0004980412,0.000434702,0.0002037558,0.0004142839,0.0002620141,0.0005240291,0.0008933435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004681265,"about_ca_system_score_gemma":0.0002831149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004539819,"about_ca_topic_score_gemma":0.0008059611,"domain_scores_codex":[0.9998591,0.00002023174,0.00001511107,0.00002697865,0.00003968677,0.00003881718],"domain_scores_gemma":[0.999795,0.00004855573,0.00003005979,0.00001481958,0.00005869738,0.00005299868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003338465,0.00004105444,0.0004184876,0.00008785694,0.00002067752,0.0001901335,0.00002377178,0.00003599502,0.9976046,0.0001292969,0.0001149721,0.0009991978],"study_design_scores_gemma":[0.00004018283,0.0002694674,0.02943103,0.00001888436,0.0001236392,0.001636327,0.0001404863,0.001735835,0.9618388,0.0002022182,0.004549097,0.00001418479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827389,0.00510605,0.006643857,0.0004230669,0.0000988562,0.00008420348,0.001682999,0.00006986548,0.003152188],"genre_scores_gemma":[0.9679675,0.005140235,0.01198582,0.0003637458,0.0001163444,0.0001532851,0.005982356,0.00004199675,0.008248796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671973,"threshold_uncertainty_score":0.0055933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497464397020827,"score_gpt":0.2740643205970354,"score_spread":0.2590896766268271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}