{"id":"W2063817872","doi":"10.1017/cjn.2015.19","title":"Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sphingosine-1-phosphate receptor; Neuroinflammation; Inflammation; Agonist; Sphingosine-1-phosphate; Receptor; Sphingosine; Lipopolysaccharide; Pharmacology; Morris water navigation task; Chemistry; Neuroscience; Biology; Endocrinology; Internal medicine; Medicine; Biochemistry; Hippocampus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213425,0.0004102736,0.0003418126,0.0002301198,0.00009870473,0.0002124159,0.0002824832,0.0004492598,0.001691306],"category_scores_gemma":[0.00006767422,0.00008331295,0.000252852,0.0001548259,0.000153298,0.000257865,0.0001276048,0.0005777802,0.0006513893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640402,"about_ca_system_score_gemma":0.0002049225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001881059,"about_ca_topic_score_gemma":0.000426175,"domain_scores_codex":[0.9999737,0.00000366144,0.000001582431,0.000004516594,0.000005475027,0.00001112071],"domain_scores_gemma":[0.9999752,0.00000257692,0.000009072178,0.000001402486,0.000004145006,0.000007593169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001627686,0.0004016767,0.0005168394,0.001110991,0.0000519757,0.0005992459,0.000033938,0.0005030262,0.9391089,0.0006403872,0.001203472,0.05420197],"study_design_scores_gemma":[0.001843899,0.01370032,0.0157914,0.000219121,0.0005450907,0.005371496,0.0001489806,0.004044673,0.8895173,0.001404365,0.0673468,0.00006661242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8654307,0.1192857,0.006403268,0.002472995,0.0002871273,0.0001602878,0.0006711645,0.0004140617,0.004874669],"genre_scores_gemma":[0.9201071,0.06719907,0.005604722,0.0005493662,0.000205063,0.0001537965,0.0009338236,0.00002300706,0.005223953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691306,"threshold_uncertainty_score":0.005658031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02176836922104527,"score_gpt":0.2458559188432659,"score_spread":0.2240875496222207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}