{"id":"W2063833780","doi":"10.1111/j.1365-2516.2006.01333.x","title":"Pharmacokinetics of recombinant factor VIII (Kogenate‐FS<sup>®</sup>) in children and causes of inter‐patient pharmacokinetic variability","year":2006,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Hospital for Sick Children","funders":"Hospital for Sick Children; Canada Research Chairs; Bayer HealthCare","keywords":"Medicine; Haemophilia A; Haemophilia; Pharmacokinetics; Von Willebrand factor; Recombinant DNA; Coagulopathy; Internal medicine; Context (archaeology); Half-life; Bolus (digestion); Gastroenterology; Immunology; Endocrinology; Surgery; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005946318,0.0002324321,0.0004082431,0.0001963556,0.0001585301,0.0004130392,0.0001433517,0.0002463982,0.0005552272],"category_scores_gemma":[0.002822062,0.0001847248,0.0002522969,0.0002908499,0.0003396683,0.0003097207,0.000164986,0.000528847,0.0001596809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005534756,"about_ca_system_score_gemma":0.000275107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002282746,"about_ca_topic_score_gemma":0.001086831,"domain_scores_codex":[0.9995764,0.0001212184,0.00004241855,0.0001016897,0.0001089783,0.00004923294],"domain_scores_gemma":[0.9980555,0.0006798831,0.0009093651,0.00006794051,0.0001322189,0.0001552662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00276672,0.000076214,0.9585416,0.0001330085,0.0001511236,0.0009020143,0.000624578,0.00104579,0.01407664,0.0001420575,0.00048858,0.02105162],"study_design_scores_gemma":[0.00007435049,0.003443521,0.9823031,0.0000264893,0.0001350325,0.004919552,0.0002904891,0.001185367,0.005198511,0.00008085367,0.002322681,0.00002005034],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983698,0.0009869873,0.0003127136,0.00002958603,0.000002826981,0.000005711083,0.0001477848,0.000009655359,0.0001349475],"genre_scores_gemma":[0.9988286,0.0004573535,0.0003565886,0.00002963931,0.000005013626,0.00001161065,0.0002316455,0.000006785454,0.00007288709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002282746,"threshold_uncertainty_score":0.004538894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716032684317336,"score_gpt":0.2916021704651107,"score_spread":0.2744418436219374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}