{"id":"W2063833780","doi":"10.1111/j.1365-2516.2006.01333.x","title":"Pharmacokinetics of recombinant factor VIII (Kogenate‐FS<sup>®</sup>) in children and causes of inter‐patient pharmacokinetic variability","year":2006,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Hospital for Sick Children","funders":"Hospital for Sick Children; Canada Research Chairs; Bayer HealthCare","keywords":"Medicine; Haemophilia A; Haemophilia; Pharmacokinetics; Von Willebrand factor; Recombinant DNA; Coagulopathy; Internal medicine; Context (archaeology); Half-life; Bolus (digestion); Gastroenterology; Immunology; Endocrinology; Surgery; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807346,0.0002855317,0.0006669599,0.0003389059,0.00003465091,0.000008359938,0.0001411557,0.0001303995,0.0003615065],"category_scores_gemma":[0.0001286374,0.0002241031,0.0001316388,0.000399627,0.0003132631,0.00006869234,0.0001451578,0.0002881079,0.000008633963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019001,"about_ca_system_score_gemma":0.00009527326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005299204,"about_ca_topic_score_gemma":0.000008167503,"domain_scores_codex":[0.9977841,0.0001661021,0.0007817846,0.0004462318,0.0004058331,0.0004159723],"domain_scores_gemma":[0.9989307,0.0001870896,0.0001544405,0.0003815925,0.0001818076,0.0001643972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000583734,0.002321663,0.9262235,0.0004500051,0.0002217112,0.00007627024,0.0006480173,0.0001106801,0.04814338,0.00008032714,0.0007955142,0.02034517],"study_design_scores_gemma":[0.007515385,0.001211766,0.7066,0.0003460879,0.0002642054,0.0001266137,0.00006054956,0.002353154,0.280039,0.0006377641,0.0005142879,0.000331193],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970321,0.0007002832,0.00001059094,0.0003892711,0.0001210917,0.001067243,0.0001027689,0.00002860726,0.0005480227],"genre_scores_gemma":[0.9988259,0.000420775,0.0002402354,0.00003268623,0.00007612818,0.00002397766,0.00007636378,0.00003334764,0.0002705884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2318956,"threshold_uncertainty_score":0.9138659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716032684317336,"score_gpt":0.2916021704651107,"score_spread":0.2744418436219374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}