{"id":"W2063852201","doi":"10.1016/s0002-9440(10)64673-1","title":"Potential Role of Modifier Genes Influencing Transforming Growth Factor-β1 Levels in the Development of Vascular Defects in Endoglin Heterozygous Mice with Hereditary Hemorrhagic Telangiectasia","year":2001,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Vascular Anomalies and Treatments","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; Hospital for Sick Children; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Endoglin; Haploinsufficiency; Telangiectasia; ACVRL1; Transforming growth factor; Medicine; Pathology; Phenotype; Biology; Gene; Internal medicine; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002218441,0.0006157429,0.0003572534,0.0008556886,0.0001844061,0.0005274289,0.000430039,0.0005907732,0.002209669],"category_scores_gemma":[0.0003459401,0.0003651109,0.0002485714,0.000190621,0.0005192482,0.0002884172,0.0002638708,0.001038643,0.0003225823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532558,"about_ca_system_score_gemma":0.0002263077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002530601,"about_ca_topic_score_gemma":0.0003181157,"domain_scores_codex":[0.9997244,0.00005397296,0.00002985911,0.00005589689,0.00007824724,0.00005746465],"domain_scores_gemma":[0.9994929,0.0001319506,0.0001780761,0.00005101755,0.00002529814,0.0001207308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001830392,0.00001576925,0.0002883004,0.000007770419,0.000003310807,0.0001852466,0.00001097301,0.00002253915,0.9986542,0.000205185,0.00001066101,0.0004129282],"study_design_scores_gemma":[0.00006946445,0.0001420372,0.008927467,0.000006278185,0.00006578461,0.0009312069,0.00004643594,0.0006357887,0.988167,0.0002338664,0.0007646692,0.00001010909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959427,0.0005394949,0.002200885,0.000120596,0.00002375522,0.00001293872,0.0002304347,0.0001359368,0.0007933272],"genre_scores_gemma":[0.9959213,0.0003210038,0.001752449,0.00004913166,0.00001019908,0.0000250183,0.0001901323,0.00009474098,0.001636099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209669,"threshold_uncertainty_score":0.007392049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01096284679564553,"score_gpt":0.2360106445723214,"score_spread":0.2250477977766759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}