{"id":"W2063853502","doi":"10.1242/dev.114488","title":"Tissue-specific genome editing in <i>Ciona</i> embryos by CRISPR/Cas9","year":2014,"lang":"en","type":"article","venue":"Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; York University; American Heart Association; National Science Foundation","keywords":"CRISPR; Ciona; Biology; Ciona intestinalis; Cas9; Genome editing; Electroporation; Zebrafish; Gene; Genetics; Gene knockout; Genome; Computational biology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071087,0.0001429219,0.0001150863,0.00004242735,0.0000497758,0.00001849155,0.0001396308,0.00008799308,0.00003459842],"category_scores_gemma":[0.00002039546,0.0001531467,0.00002117411,0.00006945762,0.00001518106,0.000001918534,0.00008699869,0.00007416698,0.00005001791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000257005,"about_ca_system_score_gemma":0.00002600927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003344373,"about_ca_topic_score_gemma":0.00001520867,"domain_scores_codex":[0.9990541,0.00001854349,0.0002280566,0.0002992782,0.0001211818,0.0002788898],"domain_scores_gemma":[0.9996786,0.000006715341,0.00003077485,0.0001850311,0.00002598611,0.00007285745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006839853,0.00003250594,0.0006078146,0.00001836665,0.0000110529,0.000002584566,0.0001945707,0.0002775858,0.9652864,0.00002887787,0.009526892,0.02400648],"study_design_scores_gemma":[0.000193857,0.00002044,0.003852862,0.000007080595,8.479302e-7,0.00000371231,0.00003135353,0.00001440159,0.4162156,0.000004613137,0.5795208,0.0001344468],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8025588,0.00314382,0.1881916,0.0002724639,0.0006058868,0.0002699269,0.000008737691,0.00003957616,0.004909221],"genre_scores_gemma":[0.9909801,0.0001148478,0.007227107,0.0002226019,0.0003059243,0.00003645973,0.0001881871,0.00002633672,0.0008983616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5699939,"threshold_uncertainty_score":0.624514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005497049869607241,"score_gpt":0.249811973623329,"score_spread":0.2443149237537217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}