{"id":"W2063855268","doi":"10.1371/journal.pone.0045633","title":"Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"University of Hong Kong","keywords":"Reprogramming; Homeobox protein NANOG; Induced pluripotent stem cell; Cell biology; Gene knockdown; Sirtuin 1; Biology; Embryonic stem cell; Sirtuin; SOX2; Rex1; KLF4; Chemistry; Molecular biology; Acetylation; Downregulation and upregulation; Cell culture; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830719,0.0004441504,0.0002747534,0.0003140155,0.0001350081,0.0002472503,0.0002149632,0.0002700409,0.001347104],"category_scores_gemma":[0.0001179069,0.0001530689,0.0004019854,0.0001557627,0.00018938,0.0002146119,0.0002656357,0.0005084908,0.0005291364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834248,"about_ca_system_score_gemma":0.0001420618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003102545,"about_ca_topic_score_gemma":0.0006146187,"domain_scores_codex":[0.9998078,0.00003206915,0.00001800829,0.00004300119,0.00007219049,0.00002690535],"domain_scores_gemma":[0.9999369,0.00001001053,0.00002156744,0.0000082685,0.000008930129,0.00001429313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000036282,0.00001063308,0.0001052788,0.00004070271,0.000004032644,0.00002923492,0.000009172055,0.00004098941,0.9974902,0.0000853966,0.00003594925,0.002112096],"study_design_scores_gemma":[0.000007992565,0.0001207861,0.001876073,0.000004750836,0.00002285598,0.0001594875,0.000008578992,0.0005980853,0.9924061,0.00004743762,0.004744115,0.00000375108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464011,0.01222576,0.03158462,0.0004193638,0.0002073349,0.0001330243,0.001129789,0.001077621,0.006821369],"genre_scores_gemma":[0.9823973,0.003030936,0.009199089,0.00008144957,0.00002534948,0.00005348413,0.0008547763,0.00006154653,0.004296091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347104,"threshold_uncertainty_score":0.004506469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08449211838676643,"score_gpt":0.243207015027228,"score_spread":0.1587148966404616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}