{"id":"W2063855268","doi":"10.1371/journal.pone.0045633","title":"Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"University of Hong Kong","keywords":"Reprogramming; Homeobox protein NANOG; Induced pluripotent stem cell; Cell biology; Gene knockdown; Sirtuin 1; Biology; Embryonic stem cell; Sirtuin; SOX2; Rex1; KLF4; Chemistry; Molecular biology; Acetylation; Downregulation and upregulation; Cell culture; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955591,0.0001794007,0.0002133949,0.00002604356,0.00009522153,0.00002726998,0.0002129351,0.0001648276,0.00002423767],"category_scores_gemma":[0.00003516693,0.0001381144,0.00006276613,0.00006882772,0.00009449491,0.00001718045,0.0002302204,0.0001389717,0.00003437895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002186969,"about_ca_system_score_gemma":0.00004342109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001022765,"about_ca_topic_score_gemma":0.00003690437,"domain_scores_codex":[0.9985156,0.0001854412,0.0002504083,0.0003185891,0.0003597715,0.0003701576],"domain_scores_gemma":[0.9991512,0.00005189948,0.0001051217,0.0004787927,0.0001058821,0.0001071149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004807002,0.0004121253,0.0003731339,0.00006793091,0.000201439,5.340376e-7,0.0004651363,0.00002212954,0.9978548,0.00001376866,0.0002834236,0.0002575111],"study_design_scores_gemma":[0.0003964687,0.0002436297,0.0004627708,0.00003169498,0.00004263526,8.392778e-7,0.0002721617,0.0003385017,0.9976248,0.00001615396,0.0004167168,0.0001536764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959605,0.002928486,0.0001266927,0.0001805583,0.000044295,0.0004361445,0.0002047671,0.00001205905,0.0001064781],"genre_scores_gemma":[0.9976734,0.000483599,0.0006476117,0.00006365187,0.000209668,0.00004246287,0.0001449618,0.00002568994,0.0007089502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444887,"threshold_uncertainty_score":0.5632139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08449211838676643,"score_gpt":0.243207015027228,"score_spread":0.1587148966404616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}