{"id":"W2063874785","doi":"10.1002/mus.20688","title":"Beneficial effects of creatine, CoQ<sub>10</sub>, and lipoic acid in mitochondrial disorders","year":2006,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Lactic acidosis; Mitochondrial myopathy; Creatine Monohydrate; MELAS syndrome; Mitochondrial encephalomyopathy; Creatine; Chronic progressive external ophthalmoplegia; Internal medicine; Kearns–Sayre syndrome; Mitochondrial disease; Mitochondrial DNA; Coenzyme Q – cytochrome c reductase; Endocrinology; Crossover study; Heteroplasmy; Mitochondrion; Medicine; Anaerobic exercise; Lipoic acid; Gastroenterology; Placebo; Biology; Biochemistry; Pathology; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008570746,0.00058233,0.001947587,0.0004281876,0.0003351549,0.0003593281,0.0002969613,0.000496342,0.001567966],"category_scores_gemma":[0.0009735813,0.0002906227,0.0004688355,0.0003509777,0.0007721331,0.000393763,0.0004076512,0.0007842477,0.0001765817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258743,"about_ca_system_score_gemma":0.0002883358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000279913,"about_ca_topic_score_gemma":0.0006676997,"domain_scores_codex":[0.9993118,0.0003819955,0.0000821162,0.00009162121,0.00006914771,0.00006343645],"domain_scores_gemma":[0.9992858,0.0002442838,0.0001690321,0.00004776779,0.00002902739,0.0002241044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6061856,0.02312068,0.0161524,0.001190483,0.002592775,0.0006463374,0.0001745988,0.00112213,0.2018617,0.0002374422,0.0004343918,0.1462814],"study_design_scores_gemma":[0.1241408,0.7731457,0.04941143,0.00008510832,0.00292974,0.001514344,0.000207727,0.001271553,0.04518406,0.0003044488,0.001754713,0.00005029539],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963446,0.002772243,0.00032866,0.00008338388,0.00003558251,0.00008183077,0.00003778723,0.00001664251,0.0002992295],"genre_scores_gemma":[0.9980757,0.0008499624,0.0006437475,0.00007427437,0.0000670981,0.00007472418,0.00005511854,0.000004747953,0.0001545658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001947587,"threshold_uncertainty_score":0.005245328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003264238017237144,"score_gpt":0.2147705969036345,"score_spread":0.2115063588863973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}