{"id":"W2063874785","doi":"10.1002/mus.20688","title":"Beneficial effects of creatine, CoQ<sub>10</sub>, and lipoic acid in mitochondrial disorders","year":2006,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Lactic acidosis; Mitochondrial myopathy; Creatine Monohydrate; MELAS syndrome; Mitochondrial encephalomyopathy; Creatine; Chronic progressive external ophthalmoplegia; Internal medicine; Kearns–Sayre syndrome; Mitochondrial disease; Mitochondrial DNA; Coenzyme Q – cytochrome c reductase; Endocrinology; Crossover study; Heteroplasmy; Mitochondrion; Medicine; Anaerobic exercise; Lipoic acid; Gastroenterology; Placebo; Biology; Biochemistry; Pathology; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007032674,0.0001656977,0.0002146625,0.00005390485,0.00004836711,0.00001355894,0.0001285459,0.0001688943,0.000005328925],"category_scores_gemma":[0.0002363598,0.0001517733,0.00008316278,0.0001369596,0.0001760435,0.000003777452,0.0002114522,0.0001090251,0.000002741388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001211521,"about_ca_system_score_gemma":0.00002646927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002571376,"about_ca_topic_score_gemma":0.0007320747,"domain_scores_codex":[0.9989058,0.00005919594,0.0002182562,0.0003480426,0.0001627021,0.0003060125],"domain_scores_gemma":[0.9995854,0.00004598709,0.00006019654,0.0002004381,0.00005203965,0.00005597653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559976,0.0001484282,0.00204331,0.0001098731,0.00002110331,0.000003596912,0.00001855227,0.00000970138,0.9911829,0.00002574902,0.001373496,0.004907261],"study_design_scores_gemma":[0.001302676,0.0003951423,0.039308,0.00003159434,0.000012789,9.027893e-7,0.00001472576,0.00002361432,0.9572295,0.0001922317,0.001326293,0.0001625079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956236,0.003122751,0.00004786596,0.000134898,0.00008841634,0.0002697764,0.00001955688,0.000008875091,0.0006842409],"genre_scores_gemma":[0.998975,0.0003116448,0.0001493757,0.00002224362,0.0003321059,0.00005257486,0.00007292571,0.0000182936,0.00006586197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0372647,"threshold_uncertainty_score":0.6189134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003264238017237144,"score_gpt":0.2147705969036345,"score_spread":0.2115063588863973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}