{"id":"W2063887542","doi":"10.1021/jm200640v","title":"3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Cancer Research UK; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Bromodomain; Acetylation; Chemistry; BRD4; Histone; Lysine; Epigenetics; Biochemistry; Chromatin; PHD finger; Histone Acetyltransferases; Transcription factor; Computational biology; Gene; Biology; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002477496,0.0005180276,0.000441867,0.0001837541,0.0001239319,0.0002311346,0.0008447265,0.0002910386,0.001327569],"category_scores_gemma":[0.0001783087,0.0002037857,0.0002703969,0.0002024919,0.0002615527,0.0002229353,0.0001714993,0.0006460235,0.0005968456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355987,"about_ca_system_score_gemma":0.000187346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395533,"about_ca_topic_score_gemma":0.0009326192,"domain_scores_codex":[0.9998716,0.00003504186,0.000008937792,0.00001952387,0.00003188463,0.00003287461],"domain_scores_gemma":[0.9999262,0.00001747939,0.00002438628,0.000008278581,0.00001058336,0.00001297576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003658842,0.0001050104,0.0001963774,0.0002045578,0.00002217085,0.00009489356,0.00002520013,0.00082422,0.9917778,0.0005532068,0.0002312878,0.005599444],"study_design_scores_gemma":[0.000223516,0.001656071,0.001274514,0.0000115698,0.0000303118,0.000348828,0.00002160071,0.0009974893,0.9846761,0.000108916,0.01063447,0.00001664253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437144,0.02965044,0.01692786,0.0003632696,0.0001414289,0.0002922806,0.001000809,0.0003389156,0.007570666],"genre_scores_gemma":[0.9709868,0.01232021,0.01024202,0.0001736848,0.00002910802,0.0001273099,0.0008957385,0.00002305249,0.005202105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327569,"threshold_uncertainty_score":0.004441202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290468324358886,"score_gpt":0.2417098870984178,"score_spread":0.228805203854829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}