{"id":"W2063887542","doi":"10.1021/jm200640v","title":"3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Cancer Research UK; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Bromodomain; Acetylation; Chemistry; BRD4; Histone; Lysine; Epigenetics; Biochemistry; Chromatin; PHD finger; Histone Acetyltransferases; Transcription factor; Computational biology; Gene; Biology; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005396327,0.000186696,0.0002647237,0.00004777332,0.00005444992,0.0000135503,0.0003594394,0.0002113747,0.0004555252],"category_scores_gemma":[0.0004590896,0.0001501649,0.0001993004,0.0001097158,0.0001435719,0.00001132213,0.00006793968,0.0003094676,0.00001328186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002584312,"about_ca_system_score_gemma":0.0002328802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008712791,"about_ca_topic_score_gemma":6.762539e-7,"domain_scores_codex":[0.9986839,0.00003140838,0.0004910951,0.0001842547,0.0003876307,0.0002217003],"domain_scores_gemma":[0.998831,0.00001538194,0.0004188871,0.0002658134,0.000212163,0.0002567166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002793639,0.0001010208,0.000626187,0.00003730686,0.00009799792,0.00005675689,0.0001010378,0.000001122645,0.9910949,0.000007330268,0.005672308,0.001924625],"study_design_scores_gemma":[0.001019952,0.0005248517,0.0004798351,0.0000921202,0.00006854563,0.00087754,0.000262324,0.00000306954,0.9815792,0.0001833436,0.01474872,0.0001604396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853076,0.002201715,0.0003215663,0.0003094926,0.000224277,0.00005181718,0.000002454793,0.000007441774,0.01157359],"genre_scores_gemma":[0.9958032,0.0003423724,0.001018105,0.0003159836,0.001092311,0.000002221779,0.00001351378,0.00002169487,0.001390558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01049559,"threshold_uncertainty_score":0.6123545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290468324358886,"score_gpt":0.2417098870984178,"score_spread":0.228805203854829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}