{"id":"W2063949146","doi":"10.1097/00126334-200309011-00013","title":"Mitochondrial Toxicity in the Era of HAART: Evaluating Venous Lactate and Peripheral Blood Mitochondrial DNA in HIV-Infected Patients Taking Antiretroviral Therapy","year":2003,"lang":"en","type":"review","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Providence Health Care; HIV Legal Network; University of British Columbia","funders":"","keywords":"Mitochondrial toxicity; Stavudine; Lamivudine; Hyperlactatemia; Didanosine; Mitochondrial DNA; Biology; Asymptomatic; Internal medicine; Nucleoside analogue; Viral load; Zidovudine; Gastroenterology; Medicine; Pharmacology; Toxicity; Immunology; Virology; Nucleoside; Viral disease; Human immunodeficiency virus (HIV); Genetics; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001177854,0.0005952081,0.002932647,0.0009247294,0.0002174364,0.00006836637,0.0004559536,0.0004050552,0.00004232099],"category_scores_gemma":[0.000775715,0.0003935717,0.0006485012,0.001631166,0.0001927671,0.0002489166,0.00005698576,0.0008795108,0.000007164179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003099198,"about_ca_system_score_gemma":0.0009527787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000738629,"about_ca_topic_score_gemma":0.000004180726,"domain_scores_codex":[0.9937135,0.001196107,0.003046786,0.0004603561,0.0009364359,0.0006468171],"domain_scores_gemma":[0.9954579,0.0005706726,0.002921061,0.0005746718,0.0003607031,0.000115002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001137818,0.01239035,0.02897331,0.006290371,0.00126834,0.000780782,0.009814932,0.00002924977,0.0009860665,0.00005604996,0.00008293853,0.9381898],"study_design_scores_gemma":[0.1478353,0.1186245,0.4360558,0.2244695,0.01616607,0.02318205,0.00216522,0.0007242184,0.0002173819,0.0005121288,0.02497228,0.005075503],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5175885,0.4805341,0.000005755955,0.00003130367,0.0005156867,0.001237692,0.00002477681,0.000009452081,0.00005267695],"genre_scores_gemma":[0.2139802,0.7844436,0.001148524,0.00003066164,0.0001134501,0.00007265634,0.00007980513,0.00009025339,0.00004089758],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9331143,"threshold_uncertainty_score":0.9998516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04031814044689733,"score_gpt":0.344507449152774,"score_spread":0.3041893087058767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}