{"id":"W2063990365","doi":"10.1158/1535-7163.mct-08-0309","title":"A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; University of Alberta","keywords":"STAT3; stat; Signal transduction; Cancer research; Tyrosine phosphorylation; Cancer cell; Cell signaling; JAK-STAT signaling pathway; Phosphorylation; Biology; PIM1; Cell culture; Cancer; Tyrosine kinase; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125459,0.0005374016,0.0003509697,0.0003907791,0.0001475807,0.0001616017,0.0002528753,0.0002451738,0.001416872],"category_scores_gemma":[0.00006042061,0.0001255914,0.0003200641,0.0002873868,0.0001124062,0.0001007238,0.000146327,0.0004062715,0.0004333034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188923,"about_ca_system_score_gemma":0.0002348067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006192694,"about_ca_topic_score_gemma":0.001928436,"domain_scores_codex":[0.9999243,0.000009471764,0.000006806425,0.00001799538,0.00002562151,0.00001580385],"domain_scores_gemma":[0.9999731,0.000005522556,0.000006555665,0.000002966033,0.000004486566,0.000007359045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001331278,0.0001467314,0.0002777941,0.0001077473,0.00001566687,0.0001080231,0.00001190507,0.0002435559,0.9931966,0.0000659169,0.0001613307,0.005531752],"study_design_scores_gemma":[0.0001369719,0.001939482,0.002831541,0.00001025225,0.00005362499,0.0004682046,0.00001461992,0.001088877,0.9898238,0.00002284177,0.003600679,0.000009152996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776732,0.008108101,0.006933005,0.0002320646,0.00009894127,0.0004239661,0.001972702,0.0003582241,0.004199762],"genre_scores_gemma":[0.9809237,0.006021626,0.005817879,0.0001056187,0.00001545704,0.0001636446,0.002331843,0.00001371509,0.004606614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416872,"threshold_uncertainty_score":0.004739881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08874461016305578,"score_gpt":0.3205069088335087,"score_spread":0.2317622986704529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}