{"id":"W2063990365","doi":"10.1158/1535-7163.mct-08-0309","title":"A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; University of Alberta","keywords":"STAT3; stat; Signal transduction; Cancer research; Tyrosine phosphorylation; Cancer cell; Cell signaling; JAK-STAT signaling pathway; Phosphorylation; Biology; PIM1; Cell culture; Cancer; Tyrosine kinase; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001500642,0.0004184193,0.0005387057,0.0002359055,0.0003116537,0.00006284117,0.0001989975,0.0001785168,0.0003826453],"category_scores_gemma":[0.000005267987,0.0004272518,0.0003063993,0.0005801996,0.000145725,0.00009787524,0.00005408678,0.0006309006,0.00001223908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074102,"about_ca_system_score_gemma":0.0004449996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002602058,"about_ca_topic_score_gemma":0.0003296947,"domain_scores_codex":[0.9975227,0.0001254405,0.0006242322,0.0006124031,0.0004882046,0.0006270745],"domain_scores_gemma":[0.9988232,0.00005937639,0.0002416481,0.000481543,0.0002445292,0.0001496757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001878263,0.0003993615,0.001246907,0.00009808804,0.0001839642,0.0007192628,0.001812181,0.007723638,0.9870224,0.0000476322,0.00008279106,0.000475977],"study_design_scores_gemma":[0.003304199,0.0002319406,0.0002824896,0.00059946,0.0001984102,0.0000320026,0.0002432914,0.00210578,0.9885557,0.000036738,0.00395323,0.0004567215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668382,0.004260179,0.0260772,0.0004674892,0.00035179,0.0006793847,0.00005825058,0.0001150628,0.001152488],"genre_scores_gemma":[0.9920814,0.0001702884,0.001674943,0.005088381,0.0001582699,0.0002218646,0.0000642649,0.0001290086,0.0004116047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02524322,"threshold_uncertainty_score":0.9998179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08874461016305578,"score_gpt":0.3205069088335087,"score_spread":0.2317622986704529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}