{"id":"W2064005519","doi":"10.1371/journal.pone.0015620","title":"Perturbation of Host Nuclear Membrane Component RanBP2 Impairs the Nuclear Import of Human Immunodeficiency Virus -1 Preintegration Complex (DNA)","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Neurological Disorders and Stroke; York University; University of South Carolina","keywords":"Nuclear transport; Biology; Nuclear pore; Cell biology; Cell nucleus; DNA; Viral replication; Nuclear DNA; Nucleoporin; Molecular biology; Virology; Cytoplasm; Virus; Genetics; Gene; Mitochondrial DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659805,0.000126297,0.0001989493,0.00003921215,0.0001460174,0.00001532481,0.0002143952,0.0001346494,0.0002759196],"category_scores_gemma":[0.00004352702,0.000096218,0.0001004866,0.00007418777,0.0001772292,0.000008606766,0.00006608031,0.0001624613,0.000008056994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000795012,"about_ca_system_score_gemma":0.00001647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000967646,"about_ca_topic_score_gemma":0.00004000694,"domain_scores_codex":[0.9990942,0.00004341147,0.0002960037,0.0001989957,0.0002370506,0.0001302893],"domain_scores_gemma":[0.9991467,0.000009210937,0.000221401,0.0004420195,0.0001501992,0.00003048575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001405448,0.000387377,0.0002134018,0.00004104849,0.00009632032,1.775209e-7,0.0002678834,0.000002998313,0.9972314,0.001326662,0.0001409818,0.0001512497],"study_design_scores_gemma":[0.0005552223,0.0007740479,0.02957853,0.00002564106,0.0001175078,0.000005793855,0.0002398776,0.0009477777,0.9659903,0.00008789164,0.001517618,0.0001597975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972078,0.0000416949,0.00001216495,0.0001412159,0.00007671944,0.000257852,0.00002502635,0.0000168631,0.002220647],"genre_scores_gemma":[0.9991066,0.00004602551,0.0003900357,0.00008334882,0.0001050102,0.000003182227,0.000139945,0.00002966222,0.00009615061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03124106,"threshold_uncertainty_score":0.3923656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787831312223014,"score_gpt":0.2154828175451377,"score_spread":0.1976045044229075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}