{"id":"W2064039041","doi":"10.1515/bc.2007.100","title":"PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by <i>Pseudomonas aeruginosa</i> and <i>Burkholderia thailandensis</i>","year":2007,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Pseudomonas aeruginosa; Burkholderia; Metabolite; Operon; Biosynthesis; Microbiology; Bacteria; Virulence; Chemistry; Metabolic pathway; Pseudomonas; Biology; Biochemistry; Enzyme; Gene; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006121954,0.0003055641,0.0003816286,0.00001388209,0.0001474519,0.00004280642,0.0002700194,0.0004435145,0.00002270124],"category_scores_gemma":[0.0003331694,0.0002003709,0.0002017035,0.000108048,0.0003567182,0.000006192492,0.0001769185,0.0001027977,0.000001182171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008097256,"about_ca_system_score_gemma":0.00003209911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002280393,"about_ca_topic_score_gemma":0.000002337119,"domain_scores_codex":[0.9982241,0.00003296286,0.0004803981,0.0006641175,0.0001283379,0.0004700515],"domain_scores_gemma":[0.9988552,0.000128214,0.000243603,0.0005105134,0.0001304973,0.0001319901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004939828,0.00006452805,0.0005223276,0.00005111862,0.0001065366,0.00000137864,0.00001787936,1.767833e-7,0.995007,0.00001102082,0.002239641,0.001484444],"study_design_scores_gemma":[0.0007000774,0.00009742637,0.0007304162,0.00001601583,0.00006643614,0.00002205104,0.00006227491,0.000006198996,0.9587038,0.00001880299,0.03930559,0.000270928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937459,0.004388877,0.0002333283,0.0006153937,0.0001536133,0.0003628414,0.0003103846,0.00002678071,0.0001628653],"genre_scores_gemma":[0.9968637,0.0008219475,0.0005973958,0.0005850333,0.0005084482,0.0000167905,0.0002421907,0.00002413862,0.0003404094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03706595,"threshold_uncertainty_score":0.8170887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812008073373773,"score_gpt":0.2447984362095915,"score_spread":0.2266783554758538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}