{"id":"W2064039041","doi":"10.1515/bc.2007.100","title":"PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by <i>Pseudomonas aeruginosa</i> and <i>Burkholderia thailandensis</i>","year":2007,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Pseudomonas aeruginosa; Burkholderia; Metabolite; Operon; Biosynthesis; Microbiology; Bacteria; Virulence; Chemistry; Metabolic pathway; Pseudomonas; Biology; Biochemistry; Enzyme; Gene; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374637,0.0002855345,0.0002342691,0.0001630632,0.000122823,0.0005130469,0.0001385177,0.0002393005,0.0007599483],"category_scores_gemma":[0.0004177239,0.0001816745,0.0001819418,0.0001534863,0.0002564271,0.0003023513,0.0003826319,0.0003073677,0.0005698403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002637113,"about_ca_system_score_gemma":0.0002942667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00177885,"about_ca_topic_score_gemma":0.00145491,"domain_scores_codex":[0.9998316,0.00003840075,0.00001825241,0.00003036533,0.00005350497,0.00002790498],"domain_scores_gemma":[0.9995955,0.0001048462,0.0001217662,0.0000358194,0.00006462951,0.00007752494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004765509,0.000005253929,0.0006339392,0.0000196144,0.000001699158,0.00006854995,0.00002364493,0.00002619407,0.9986753,0.00002703966,0.000009904815,0.0004612044],"study_design_scores_gemma":[0.00001591692,0.000190166,0.03044882,0.00001164882,0.00001331571,0.001517885,0.0002516528,0.001173903,0.9638192,0.0001161533,0.002427291,0.00001400218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968287,0.0006150453,0.001686532,0.0000601225,0.00000764022,0.000008674687,0.0002943004,0.00005148341,0.000447507],"genre_scores_gemma":[0.9972118,0.0002279742,0.001246684,0.00001687508,0.000002908627,0.000007423545,0.0006799675,0.00001865108,0.0005878719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177885,"threshold_uncertainty_score":0.003536999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812008073373773,"score_gpt":0.2447984362095915,"score_spread":0.2266783554758538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}