{"id":"W2064064687","doi":"10.1016/j.bcp.2004.10.014","title":"Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas","year":2004,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Cancer Institute; Ligue Contre le Cancer","keywords":"Glibenclamide; Tolbutamide; Sulfonylurea receptor; Sulfonylurea; Chemistry; Glutathione; Biochemistry; Transmembrane domain; Receptor; Biology; Enzyme; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136326,0.0001940139,0.0004950829,0.0001337695,0.00002473025,0.000001701431,0.00004647759,0.0001489435,0.00004516725],"category_scores_gemma":[0.00001173255,0.0001769809,0.00007812757,0.0002392464,0.0001549282,0.00003841244,0.00002243065,0.0002567231,0.000005326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080859,"about_ca_system_score_gemma":0.0001277621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248912,"about_ca_topic_score_gemma":0.0001586431,"domain_scores_codex":[0.9987914,0.00003632759,0.0002670444,0.0003860128,0.0001770086,0.0003421873],"domain_scores_gemma":[0.9994612,0.00003958202,0.00005503722,0.0001340942,0.00005660581,0.0002535019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002084176,0.000608335,0.005457499,0.000109083,0.00003894954,0.00021827,0.0001856653,0.00003408163,0.9906591,0.0001444816,0.0002224245,0.0002379708],"study_design_scores_gemma":[0.004214202,0.0001671491,0.09114527,0.00008459056,0.0001185956,0.00005798666,0.00002972926,0.0000182746,0.9034753,0.0002467735,0.0002921026,0.0001500236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965423,0.0005767755,0.0002165643,0.001780655,0.0001097295,0.0005018109,0.00003523445,0.00004275332,0.0001941185],"genre_scores_gemma":[0.9980964,0.0001361458,0.001116819,0.0004413954,0.0001020587,0.00002089144,0.00002130152,0.00002008288,0.00004487496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08718376,"threshold_uncertainty_score":0.7217072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008835456917760918,"score_gpt":0.2819285745849459,"score_spread":0.2730931176671849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}