{"id":"W2064069620","doi":"10.1194/jlr.m041533","title":"Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation","year":2013,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; British Heart Foundation; Wellcome Trust","keywords":"Chemistry; Platelet; Phosphatidylethanolamine; Platelet activation; Arachidonic acid; Cyclooxygenase; Phospholipid; Biochemistry; Lipid signaling; Phospholipase A2; Prostaglandin; In vitro; Agonist; Thrombin; Pharmacology; Internal medicine; Phosphatidylcholine; Receptor; Enzyme; Membrane; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002323756,0.0002512092,0.0005490949,0.0005918191,0.0003045716,0.0001696821,0.0002224184,0.0002033355,0.001183442],"category_scores_gemma":[0.0001466567,0.0001845566,0.0001662964,0.0004246631,0.0001471629,0.0004413751,0.00008641955,0.001132657,0.0002083217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884005,"about_ca_system_score_gemma":0.0002156105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001132329,"about_ca_topic_score_gemma":0.0000193276,"domain_scores_codex":[0.9961551,0.0004308322,0.0007809682,0.0002755696,0.001609197,0.0007482609],"domain_scores_gemma":[0.9975068,0.0001263952,0.0004924787,0.0003140054,0.0009312311,0.0006290674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005515837,0.0005085368,0.03253189,0.0003826018,0.0001221523,0.0004287678,0.00055784,0.000007471532,0.806061,0.000005474993,0.1562486,0.002594052],"study_design_scores_gemma":[0.01090333,0.00297298,0.1030212,0.000878176,0.00005237272,0.0004126238,0.0006871435,0.0005033843,0.8647914,0.00005505549,0.01536762,0.0003547544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962029,0.0002201034,0.0000386692,0.00150496,0.0005574984,0.001186654,0.00002125354,0.00002267045,0.0002452171],"genre_scores_gemma":[0.9956971,0.0001320323,0.0001306263,0.0003073174,0.002018116,0.00006723862,0.00009219502,0.00005919996,0.00149612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.140881,"threshold_uncertainty_score":0.9997296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04998900199222684,"score_gpt":0.3552775491098485,"score_spread":0.3052885471176217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}