{"id":"W2064069620","doi":"10.1194/jlr.m041533","title":"Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation","year":2013,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; British Heart Foundation; Wellcome Trust","keywords":"Chemistry; Platelet; Phosphatidylethanolamine; Platelet activation; Arachidonic acid; Cyclooxygenase; Phospholipid; Biochemistry; Lipid signaling; Phospholipase A2; Prostaglandin; In vitro; Agonist; Thrombin; Pharmacology; Internal medicine; Phosphatidylcholine; Receptor; Enzyme; Membrane; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008916507,0.0002809316,0.0001393121,0.0001218049,0.00007927037,0.0001665325,0.00007546184,0.0001080372,0.001206487],"category_scores_gemma":[0.000136758,0.00009152122,0.0001328044,0.00008418175,0.00008181947,0.00008860041,0.0001167838,0.000269305,0.000296967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001183344,"about_ca_system_score_gemma":0.0001150582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309393,"about_ca_topic_score_gemma":0.0004521837,"domain_scores_codex":[0.9999276,0.00001632636,0.000006427018,0.000009882623,0.0000241079,0.00001568109],"domain_scores_gemma":[0.9999673,0.000007638074,0.000009960795,0.000004339365,0.000004279731,0.000006411533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003140262,0.00002333414,0.0005630548,0.00004028338,0.00000684462,0.0001186703,0.00002252067,0.00002266844,0.9960751,0.00005041661,0.00006668492,0.002696293],"study_design_scores_gemma":[0.000035386,0.0006363176,0.01169966,0.000007892222,0.00002720347,0.0004620602,0.0000294,0.0004556686,0.9839906,0.00005622752,0.002596672,0.000002879726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931552,0.003181843,0.001721502,0.0001059979,0.00002158534,0.00005298286,0.0003227312,0.00004322591,0.00139505],"genre_scores_gemma":[0.9955332,0.001514832,0.000843259,0.00003711,0.00001327343,0.00004273151,0.0004844443,0.000003825257,0.001527216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206487,"threshold_uncertainty_score":0.004036129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04998900199222684,"score_gpt":0.3552775491098485,"score_spread":0.3052885471176217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}