{"id":"W2064110771","doi":"10.1021/jm061294n","title":"Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr-<i>c</i>[<scp>d</scp>-Cys-Gly-Phe-<scp>d</scp>(or<scp>l</scp>)-Cys]NH<sub>2</sub>Retain High Opioid Activity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Stereochemistry; Agonist; Cyclic peptide; Tripeptide; Peptide; Enkephalin; Oligopeptide; Opioid peptide; Peptide synthesis; Metathesis; Ring-closing metathesis; Chemical synthesis; Receptor; Opioid; Biochemistry; Organic chemistry; In vitro; Polymerization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183688,0.0003399983,0.000288882,0.0001214631,0.000134221,0.000196694,0.0002353036,0.0002299739,0.002108929],"category_scores_gemma":[0.0001872242,0.0001329844,0.000176962,0.0001605622,0.0002340173,0.000207724,0.0001657356,0.0005978699,0.0006027771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485041,"about_ca_system_score_gemma":0.0001529529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000335395,"about_ca_topic_score_gemma":0.0006481783,"domain_scores_codex":[0.999881,0.00001850915,0.00001184496,0.00002944304,0.00002541933,0.00003381136],"domain_scores_gemma":[0.999826,0.00002507556,0.00005222807,0.00002206916,0.00002732353,0.00004738254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001942299,0.00001417076,0.00005736449,0.00002689148,0.000005020337,0.00003652323,0.000009739094,0.00005622385,0.998176,0.00008176817,0.00002469462,0.001317522],"study_design_scores_gemma":[0.00002970854,0.0006990826,0.0009354156,0.000003518815,0.00001529855,0.000341365,0.00001482353,0.0001837625,0.9959762,0.00002614721,0.001768602,0.000006204722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931198,0.001412698,0.001558159,0.00005432622,0.00002880594,0.0000281172,0.0002658537,0.00003238363,0.003499848],"genre_scores_gemma":[0.992775,0.0006732595,0.003745294,0.00007690783,0.00001551407,0.0000234914,0.000471149,0.00002369869,0.002195849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002108929,"threshold_uncertainty_score":0.007055104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908155686266925,"score_gpt":0.2550509659702933,"score_spread":0.235969409107624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}