{"id":"W2064110771","doi":"10.1021/jm061294n","title":"Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr-<i>c</i>[<scp>d</scp>-Cys-Gly-Phe-<scp>d</scp>(or<scp>l</scp>)-Cys]NH<sub>2</sub>Retain High Opioid Activity","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Stereochemistry; Agonist; Cyclic peptide; Tripeptide; Peptide; Enkephalin; Oligopeptide; Opioid peptide; Peptide synthesis; Metathesis; Ring-closing metathesis; Chemical synthesis; Receptor; Opioid; Biochemistry; Organic chemistry; In vitro; Polymerization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002047195,0.0009520645,0.001657386,0.0002573646,0.0004944548,0.0001103866,0.002292228,0.0005789544,0.00002638052],"category_scores_gemma":[0.01655333,0.0006574105,0.000922468,0.001225092,0.00163723,0.0005384748,0.0006297579,0.003072123,0.00003404133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455998,"about_ca_system_score_gemma":0.0006329934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004731183,"about_ca_topic_score_gemma":0.00001876367,"domain_scores_codex":[0.9924477,0.0005086621,0.001980392,0.001085895,0.002353923,0.001623394],"domain_scores_gemma":[0.9865932,0.008028512,0.002931056,0.001011428,0.000449741,0.0009860613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454773,0.000587296,0.00165,0.0003915866,0.0001109536,0.0009721886,0.0005976988,0.00006242636,0.9815462,0.00004473826,0.0116386,0.00225285],"study_design_scores_gemma":[0.00176438,0.0009791341,0.02585073,0.0005984906,0.0002641292,0.001514133,0.001597162,0.00005224951,0.952565,0.0007580199,0.01391821,0.000138388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930702,0.0008120144,0.00008523335,0.0002153464,0.0008389154,0.0003091204,0.00008512954,0.00008562994,0.004498372],"genre_scores_gemma":[0.9928808,0.001537261,0.0001007056,0.001409276,0.002477103,0.000008492457,0.000007868353,0.0001269698,0.001451578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02898121,"threshold_uncertainty_score":0.9995877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908155686266925,"score_gpt":0.2550509659702933,"score_spread":0.235969409107624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}