{"id":"W2064127635","doi":"10.1038/embor.2012.14","title":"Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment","year":2012,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":702,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Ottawa; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"PINK1; Parkin; Mitophagy; Mitochondrion; Cell biology; Biology; Ubiquitin ligase; Ubiquitin; Autophagy; Biochemistry; Parkinson's disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899143,0.000281012,0.0002055879,0.0001954262,0.0001463725,0.0004817244,0.0001223077,0.0002075535,0.0006054234],"category_scores_gemma":[0.0002172521,0.000153657,0.000120522,0.0001157305,0.0001962201,0.0002308595,0.00022346,0.0002561769,0.0003108356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455672,"about_ca_system_score_gemma":0.0001541245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607007,"about_ca_topic_score_gemma":0.0005658967,"domain_scores_codex":[0.9998778,0.00002058028,0.00001291523,0.00003426852,0.00002957632,0.00002490457],"domain_scores_gemma":[0.999864,0.00001849266,0.00006483048,0.000007680224,0.00001312459,0.00003190203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009654929,0.000007257554,0.0004352071,0.00001916459,0.000002897372,0.0001111507,0.000007186942,0.00006755787,0.9981286,0.000066541,0.00003460952,0.001023395],"study_design_scores_gemma":[0.00001897633,0.00009393792,0.01647339,0.000004060489,0.0000135129,0.0008447772,0.00002686922,0.001249299,0.9796902,0.0001135555,0.001466409,0.000005035205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922748,0.002584222,0.003440729,0.0001404654,0.00001451782,0.00002106679,0.0002475647,0.00006964646,0.001206933],"genre_scores_gemma":[0.9960341,0.0008206575,0.001870006,0.00004245268,0.000005526083,0.00001114396,0.0002142698,0.000015123,0.0009867472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006054234,"threshold_uncertainty_score":0.002507329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03639433169736897,"score_gpt":0.3221536096137595,"score_spread":0.2857592779163906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}