{"id":"W2064180257","doi":"10.1021/bi030188+","title":"Binding of Bovine Pancreatic Trypsin Inhibitor to Trypsinogen:  Spectroscopic and Volumetric Studies","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"thermodynamics and calorimetric analyses","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Trypsinogen; Chemistry; Enthalpy; Compressibility; Thermodynamics; Entropy (arrow of time); Crystallography; Trypsin; Biochemistry; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007715934,0.000224375,0.0004105382,0.0001485196,0.00009079272,0.00003299048,0.0001723992,0.0001284726,0.0001043896],"category_scores_gemma":[0.0003262961,0.0002125038,0.00009280094,0.0007447169,0.0001385068,0.000032291,0.0001216957,0.0001230629,0.00001277568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119526,"about_ca_system_score_gemma":0.0000951968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004532253,"about_ca_topic_score_gemma":0.000002179561,"domain_scores_codex":[0.9987636,0.000004774306,0.0003418755,0.0003735248,0.0002401741,0.0002760546],"domain_scores_gemma":[0.9992326,0.00006141247,0.0001399963,0.0003312073,0.00008234935,0.0001524686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003574192,0.00008542763,0.003214977,0.0004067358,0.0001650061,0.000009353015,0.0001068058,0.000003802268,0.9948526,0.00005464448,0.0001247531,0.0009401275],"study_design_scores_gemma":[0.0006655456,0.00006596027,0.0005097364,0.00021702,0.0001196058,0.00001082363,0.0007439458,0.00001982586,0.9971442,0.0001672553,0.0001005303,0.0002355945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903805,0.007789614,0.00009539965,0.0000875741,0.00005644647,0.00004681518,0.00003815307,0.00004531592,0.001460196],"genre_scores_gemma":[0.9967075,0.0002699296,0.001186141,0.00002299871,0.0002036633,0.000009878943,0.00001608361,0.00002473481,0.0015591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007519684,"threshold_uncertainty_score":0.8665655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615120196670216,"score_gpt":0.2709065655252264,"score_spread":0.2547553635585242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}