{"id":"W2064182959","doi":"10.1038/ncomms6264","title":"Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Senri Life Science Foundation; Inamori Foundation; Novartis Foundation; Takeda Science Foundation; Suzuken Memorial Foundation","keywords":"Senescence; Cell biology; Downregulation and upregulation; Biology; Cell cycle checkpoint; Carcinogenesis; Mitochondrion; DNA damage; Phenotype; Cell cycle; Cell; Genetics; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009065679,0.0002217337,0.0001472883,0.0003205638,0.0001822604,0.0003135309,0.0002058301,0.0003683813,0.001122481],"category_scores_gemma":[0.0001745242,0.0001716769,0.0002240946,0.000118606,0.0002353121,0.0002085629,0.0003159272,0.0004971896,0.0002370553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198354,"about_ca_system_score_gemma":0.0001095288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005314894,"about_ca_topic_score_gemma":0.001408023,"domain_scores_codex":[0.9999133,0.00001335642,0.00001401381,0.00001927264,0.00002230304,0.0000176155],"domain_scores_gemma":[0.9997411,0.00005618424,0.00008620894,0.00003861372,0.00001471339,0.00006321483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009526685,0.000007535024,0.0002956935,0.00001717446,0.000003613907,0.0001010802,0.00002012331,0.0000558781,0.998691,0.0001187829,0.00002741679,0.0005665233],"study_design_scores_gemma":[0.00005879017,0.0002681121,0.0328722,0.0000161475,0.0000271945,0.0006808839,0.0001474581,0.001721709,0.9616387,0.0001900702,0.002365815,0.0000129751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978161,0.0004100621,0.0006561569,0.00004492501,0.00001119612,0.000005528441,0.0002247288,0.00005230742,0.0007789826],"genre_scores_gemma":[0.9973556,0.0002753687,0.0005725115,0.00003008533,0.000004137548,0.000008761035,0.0001815124,0.00001991762,0.00155216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001122481,"threshold_uncertainty_score":0.003755033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144768898838157,"score_gpt":0.2700851477387428,"score_spread":0.2556082578549271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}