{"id":"W2064297266","doi":"10.1158/1538-7445.am10-3532","title":"Abstract 3532: P-glycoprotein downregulation using RNAi decreases cholesterol efflux from human renal cancer cells","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cholesterol; Kidney; Biology; HMG-CoA reductase; Internal medicine; Endocrinology; RNA interference; Knockout mouse; Medicine; Reductase; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840432,0.0003445105,0.0005975483,0.0002697732,0.0002732729,0.0004187885,0.0002825171,0.0004787192,0.003383444],"category_scores_gemma":[0.0001156979,0.0001712079,0.0004939573,0.0003780793,0.0002517838,0.0001860038,0.0001976447,0.0008474713,0.001154691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003122459,"about_ca_system_score_gemma":0.0004407365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513598,"about_ca_topic_score_gemma":0.00152464,"domain_scores_codex":[0.9997278,0.00002803665,0.00003188302,0.0000619138,0.00009339304,0.00005681974],"domain_scores_gemma":[0.999941,0.0000109836,0.00001307476,0.000009462487,0.00001261663,0.00001285573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001738416,0.00006954046,0.0001470559,0.0001053272,0.00001510508,0.00009227016,0.00003091438,0.00005577851,0.9966866,0.000101157,0.000635681,0.001886695],"study_design_scores_gemma":[0.00007645538,0.000533639,0.003736981,0.00001300852,0.00005985876,0.0004280901,0.00004319635,0.0008769052,0.9835473,0.00004700901,0.01062802,0.000009439202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975189,0.005307322,0.005782659,0.0006663602,0.0002442225,0.0002171518,0.005566462,0.0006873551,0.006339379],"genre_scores_gemma":[0.9697365,0.003315211,0.004859406,0.0002572396,0.00004178571,0.0003579349,0.007998247,0.00009187638,0.01334186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003383444,"threshold_uncertainty_score":0.0113188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05067886461738437,"score_gpt":0.3904106961664212,"score_spread":0.3397318315490368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}