{"id":"W2064332425","doi":"10.1111/j.1471-4159.2004.02360.x","title":"The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McMaster University","funders":"Canadian Institutes of Health Research; Scottish Rite Charitable Foundation of Canada; Ontario Neurotrauma Foundation","keywords":"Nerve growth factor; Neurite; Tropomyosin receptor kinase A; Neurotrophin; Low-affinity nerve growth factor receptor; Neurotrophic factors; Biology; Brain-derived neurotrophic factor; Cell biology; Growth factor; Internal medicine; In vivo; Chemistry; Endocrinology; Receptor; Biochemistry; In vitro; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410526,0.0003486119,0.0003100224,0.0002827783,0.0001048875,0.000492593,0.0002015661,0.000311929,0.001211872],"category_scores_gemma":[0.0003382149,0.000115408,0.0001571323,0.0002075892,0.0002424551,0.0004131875,0.0001666568,0.0003543088,0.0004101784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003472513,"about_ca_system_score_gemma":0.0002710644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436281,"about_ca_topic_score_gemma":0.001485506,"domain_scores_codex":[0.9997607,0.00002544547,0.00002654949,0.00006696531,0.00008935662,0.00003099998],"domain_scores_gemma":[0.9996362,0.00008068568,0.0000829106,0.00003141345,0.00006968674,0.00009905579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005302155,0.000006480349,0.0004194728,0.00004223579,0.000003051211,0.00008433544,0.00001116659,0.00002194721,0.9969608,0.00005207234,0.00001319301,0.002332195],"study_design_scores_gemma":[0.00001297669,0.0005590779,0.01797133,0.00001954788,0.00001902122,0.003268735,0.00007178658,0.0002231711,0.9696899,0.000111271,0.008044248,0.000008851724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885633,0.005855449,0.003046383,0.0001157975,0.00003219296,0.00001727662,0.0003501054,0.0000454842,0.001973999],"genre_scores_gemma":[0.9867327,0.002285566,0.005772185,0.00008077906,0.00001682464,0.00002554813,0.001486444,0.00002039534,0.003579589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001436281,"threshold_uncertainty_score":0.004054129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03013095153305255,"score_gpt":0.2640759285241194,"score_spread":0.2339449769910668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}