{"id":"W2064368016","doi":"10.1021/bi1013563","title":"Interaction between CK2α and CK2β, the Subunits of Protein Kinase CK2: Thermodynamic Contributions of Key Residues on the CK2α Surface","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Isothermal titration calorimetry; Casein kinase 2; Chemistry; Alanine scanning; Tetramer; Protein subunit; Allosteric regulation; Alanine; Biochemistry; Protein–protein interaction; Plasma protein binding; Amino acid; Mutagenesis; Mutant; Kinase; Protein kinase A; Enzyme; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136104,0.0004361304,0.0002940824,0.0001069876,0.0002426788,0.000387759,0.0003049684,0.0002151122,0.001110389],"category_scores_gemma":[0.0003541096,0.0002030607,0.0002418595,0.0001145723,0.0002870001,0.0003470338,0.0002634384,0.0004778682,0.0001939909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004255922,"about_ca_system_score_gemma":0.0001668641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000980855,"about_ca_topic_score_gemma":0.0008548036,"domain_scores_codex":[0.9997494,0.00004067974,0.00001110846,0.00005971152,0.00008127066,0.00005791895],"domain_scores_gemma":[0.9998962,0.00003239952,0.00002152446,0.000006976974,0.00001820635,0.00002462699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001713527,0.00002205472,0.0009804118,0.0000395627,0.00001621657,0.0000346804,0.00002696527,0.0004777783,0.9971118,0.0001217309,0.00003531747,0.0009621262],"study_design_scores_gemma":[0.00001842919,0.0001188781,0.01042814,0.000006935792,0.00002693287,0.0002164743,0.00006564569,0.01098669,0.9768932,0.0001511007,0.001073546,0.0000141004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968461,0.0007719527,0.00175906,0.00003999744,0.00001272951,0.000005801222,0.00004699928,0.0000116478,0.000505604],"genre_scores_gemma":[0.9986512,0.0001839377,0.0005490277,0.0000186919,0.00000453238,0.000006904901,0.0001214408,0.000008615025,0.0004557763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001110389,"threshold_uncertainty_score":0.003714561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009622215746123822,"score_gpt":0.2523352864070709,"score_spread":0.2427130706609471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}