{"id":"W2064368016","doi":"10.1021/bi1013563","title":"Interaction between CK2α and CK2β, the Subunits of Protein Kinase CK2: Thermodynamic Contributions of Key Residues on the CK2α Surface","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Isothermal titration calorimetry; Casein kinase 2; Chemistry; Alanine scanning; Tetramer; Protein subunit; Allosteric regulation; Alanine; Biochemistry; Protein–protein interaction; Plasma protein binding; Amino acid; Mutagenesis; Mutant; Kinase; Protein kinase A; Enzyme; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000377437,0.0001420774,0.0001366628,0.00001538818,0.0001264864,0.00001696149,0.0002010672,0.0001846033,0.00002408018],"category_scores_gemma":[0.0003524421,0.00009252804,0.00007501,0.00009109413,0.0002886094,0.000003868972,0.00008463953,0.0002227555,0.000001140372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009297547,"about_ca_system_score_gemma":0.00007894394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003262122,"about_ca_topic_score_gemma":0.00001393685,"domain_scores_codex":[0.999176,0.00007975218,0.0002417039,0.000215124,0.0001447684,0.0001426195],"domain_scores_gemma":[0.9990209,0.00007115662,0.0002166364,0.000465288,0.0001767368,0.00004923916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006570129,0.00003305229,0.0006425406,0.00003560744,0.00003981699,3.719315e-7,0.00002788078,0.000008921955,0.9980529,0.0005639094,0.00008708794,0.0004422224],"study_design_scores_gemma":[0.0002519749,0.00006571002,0.002118344,0.00006567904,0.00002272495,0.000003894638,0.0001182792,0.0001017306,0.995994,0.0001890004,0.0009649763,0.0001036295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977239,0.0003800027,0.0001362637,0.000780933,0.00003417403,0.0003060824,0.0001254974,0.000008663327,0.0005044429],"genre_scores_gemma":[0.9993662,0.00002160981,0.00008306168,0.00003348685,0.000127575,0.00001954778,0.000112262,0.00001305147,0.0002232235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205883,"threshold_uncertainty_score":0.3773184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009622215746123822,"score_gpt":0.2523352864070709,"score_spread":0.2427130706609471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}